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dc.contributor.authorGeinitz, Hans
dc.contributor.authorNieder, Carsten
dc.contributor.authorKocik, Lukas
dc.contributor.authorTrack, Christine
dc.contributor.authorFeichtinger, Johann
dc.contributor.authorWeingartner, Theresa
dc.contributor.authorSpiegl, Kurt J.
dc.contributor.authorFüreder-Kitzmüller, Barbara
dc.contributor.authorKaufmann, Johanna
dc.contributor.authorSeewald, Dietmar H.
dc.contributor.authorFügger, Reinhold
dc.contributor.authorShamiyeh, Andreas
dc.contributor.authorPetzer, Andreas L.
dc.contributor.authorKiesl, David
dc.contributor.authorHammer, Josef
dc.date.accessioned2020-08-11T10:58:57Z
dc.date.available2020-08-11T10:58:57Z
dc.date.issued2020-05-14
dc.description.abstract<i>Purpose</i>: To report the long-term outcomes of neoadjuvant altered fractionation short-course radiotherapy in 271 consecutive patients with stage II-III rectal cancer.<p> <p><i>Patients and Methods</i>: This was a retrospective single institution study with median follow-up of 101 months (8.4 years). Patients who were alive at the time of analysis in 2018 were contacted to obtain functional outcome data (phone interview). Radiotherapy consisted of 25 Gy in 10 fractions of 2.5 Gy administered twice daily. Median time interval to surgery was 5 days.<p> <p><i>Results</i>: Local relapse was observed in 12 patients (4.4%) after a median of 28 months. Overall survival after 5 and 10 years was 73 and 55.5%, respectively (corresponding disease-free survival 65.5 and 51%). Of all patients without permanent stoma, 79% reported no low anterior resection syndrome (LARS; 0–20 points), 9% reported LARS with 21–29 points and 12% serious LARS (30–42 points).<p> <p><i>Conclusion</i>: The present radiotherapy regimen was feasible and resulted in low rates of local relapse. Most patients reported good functional outcomes.en_US
dc.identifier.citationGeinitz, Nieder, Kocik, Track, Feichtinger, Weingartner, Spiegl, Füreder-Kitzmüller, Kaufmann, Seewald, Függer, Shamiyeh, Petzer, Kiesl, Hammer. Altered fractionation short-course radiotherapy for stage II-III rectal cancer: A retrospective study. Radiation Oncology. 2020;15en_US
dc.identifier.cristinIDFRIDAID 1821636
dc.identifier.doi10.1186/s13014-020-01566-8
dc.identifier.issn1748-717X
dc.identifier.urihttps://hdl.handle.net/10037/18944
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalRadiation Oncology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleAltered fractionation short-course radiotherapy for stage II-III rectal cancer: A retrospective studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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