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norskBlar i tittel Mastergradsoppgaver i farmasi
Viser treff 200-219 av 294
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Lipidklasser og fettsyresammensetning i brunpølse (Cucumaria frondosa)
(Master thesis; Mastergradsoppgave, 2011-05-20)Different species of the sea cucumber are a well utilized resource in eastern parts of Asia, but not much used in western parts of the world. The annual harvest of sea cucumbers in Asian waters has been estimated to be over 100,000 tons. This has led to overfishing and decreasing catches. As a result, a demand for new fishing areas has occurred. Different species of sea cucumbers are observed in ... -
Lipidklasser og fettsyresammensetning i omega-3 produkter
(Master thesis; Mastergradsoppgave, 2012-05-20)Nasjonalt råd for ernæring anbefaler å spise fisk og sjømat fordi de innholder de flerumettede omega-3 fettsyrene eikosapentaensyre (EPA: 20:5n-3) og dokosahekaensyre (DHA: 22: 6n-3). Mye forskning viser kobling mellom omega-3 fettsyrene og helsegevinster. Helsegevinstene er at disse fettsyrene er betennelsesdempende, de reduserer risiko for å utvikle sykdommer som revmatoid artritt, hjerte -kar ... -
Lipidomics of marine microalgae with industrial potential
(Mastergradsoppgave; Master thesis, 2021-05-11)Two species diatoms, Porosira glacialis and Coscinodicus radiatus were cultivated under red-, white- or blue light. The biomass from cultivation was extracted for lipids which were subsequently analyzed using UHPLC-MS and the software lipidsearch. The aim was to investigate omega-3 long chain fatty acid content differences in the different cultivations. Findings suggest that blue light cultivation ... -
Liposomal formulations for membrane active antimicrobials – Assuring safety through an optimised drug delivery system
(Master thesis; Mastergradsoppgave, 2020-05-13)Skin and soft tissue infections (SSTIs) and chronic wounds are major challenges for the healthcare system worldwide. The additional rapid development of antibacterial resistance and lack of successful treatment strategies increase the chance for infected chronic wounds to be fatal for the patient. Therefore, there is a need for more efficient dermal antimicrobial therapies. A class of promising ... -
Liposomes as drug delivery system in mitochondrial targeting
(Master thesis; Mastergradsoppgave, 2012-05-20)The mitochondrion is a subcellular organelle with major functions related to energy production and control of apoptosis. The presence of mitochondria as a subcellular organelle has been known for more than one and a half century. However, only the last decades’ research has discovered their role in ageing and disease pathology, which have led to increasing interest in mitochondria as target for drug ... -
Liposomes as Potential Carrier for Bioactive β2,2- Amino Acid Derivatives - A Feasibility Study
(Master thesis; Mastergradsoppgave, 2015-05-13)The emergence of antibiotic resistant bacterial strains is a rising global problem that does not only result in fatal infections of previously treatable cases, but increases also the economic burden of health care systems. The same applies for cancer as treatment of some cancer types is difficult and also resistance to treatment is an increasing problem in cancer chemotherapy. Novel treatment ... -
Liposomes-in-hydrogel delivery system containing resveratrol for the local treatment of vaginal infections
(Mastergradsoppgave; Master thesis, 2018-05-15)Administering drug formulations to the vagina is a challenge since the vagina possesses “self-cleaning” features which allow trapping and rapid removing of foreign particles. Therefore, the residence time of drugs is often too short to offer a sufficient clinical effect. The aim of this project was to develop and optimize a liposomes-in-hydrogel system containing resveratrol for the local treatment ... -
Mass Spectrometry Based Metabolomic and Lipidomic Analyses of Algal Biomass.
(Mastergradsoppgave; Master thesis, 2023-05-14)Background: In a project at UiT - the Arctic University of Norway, the lipid profile of the microalgal biomass from the specie Porosira glacialis is mapped using HRMS lipidomic analyses to evaluate the potential for the biomass to be used as fish feed. At the same time, it is desired to screen the same biomass for bioactivities using bioassays in combination with HRMS metabolomic analyses. ... -
Medication Assessment Tool for evaluering av antibiotikabehandling for pasienter med samfunnservervet pneumoni (MAT-CAP) i sykehus. Oppdatering, videreutvikling og applisering
(Master thesis; Mastergradsoppgave, 2015-05-13)Bakgrunn: Medication Assessment Tool (MAT) er et verktøy som brukes for undersøke hvorvidt forskrivning av legemidler er i henhold til kliniske retningslinjer. Et MAT for å undersøke behandling av CAP (MAT-CAP) ble utviklet i 2009 basert på lokale og internasjonale retningslinjer. I 2013 ble det i Norge publisert en nasjonal retningslinje for bruk av antibiotika i sykehus. Formål: å oppdatere og ... -
Medicine articles on English Wikipedia: Quantifying the presence of pharmaceutical industry edits and analyzing their content.
(Mastergradsoppgave; Master thesis, 2022-05-11)Today, Wikipedia has developed into a prominent source for health queries to the vast public. Over the years, some studies have been performed to understand what the webpage can and cannot offer. However, the current literature lacks knowledge of how the pharmaceutical industry is present in Wikipedia’s medicine articles. The immediate objective of this research was to quantify the presence of ... -
Melt processability of amorphous solid dispersions during hot-melt extrusion. Screening using vacuum compression moulding and evaluation by rheology and solid-state analysis
(Master thesis; Mastergradsoppgave, 2018-05-15)Soluplus is a suitable excipient for innovative manufacturing techniques such as hot-melt extrusion (HME). While Soluplus is useful for forming amorphous solid dispersions (ASD’s) during HME, the resulting extrudates are often stiff and brittle. In order to achieve suitable dosage forms, with optimal downstream processability, an efficient screening for suitable formulations is required. Vacuum ... -
Mercaptoalkanol-derived self-immolative linkers for bioconjugates. Synthesis and analysis
(Master thesis; Mastergradsoppgave, 2021-01-11)Many of the anticancer compounds discovered through synthesis or bioprospecting activities are found to be equally toxic to healthy cells and tumors. Consequently, these compounds are not considered as promising drug candidates worthy of further study. This project seeks to develop a novel chemical toolkit that can be utilized to increase the therapeutic value of such toxic compounds by decreasing ... -
Metabolic profiling of marine sponges as a tool to discover novel natural products
(Master thesis; Mastergradsoppgave, 2014-05-20)In this project metabolic profiling was explored as a means for finding unique and novel natural products. Natural products have had a vital role in drug discovery throughout history and in recent times, that includes the world oceans more and more. Therefore two related species of marine sponges, where the samples were collected from different locations, was chosen to test the methodology. This ... -
Metodeutvikling og innledende kompatibilitetsstudie mellom antiinfektiva og Olimel N5E gjennom Y-sett infusjon til barn fra 10 - 50 kg
(Master thesis; Mastergradsoppgave, 2011-06)Total parenteral ernæring (TPN) gis forebyggende eller korrigerende mot feilernæring til pasienter hvor oral eller enteral ernæring vanskelig lar seg gjøre. TPN inneholder glukose, fett og aminorsyrer i tillegg til viktige vitaminer, sporelementer og elektrolytter. TPN er en steril olje-i-vann (o/v) emulsjon, stabilisert ved hjelp av en lecitin-emulgator. Scenario hvor legemiddel og TPN må administreres ... -
Microfluidized liposomes for cellular uptake imaging: Optimization
(Mastergradsoppgave; Master thesis, 2020-05-14)Liposomes as drug delivery systems exhibit great potential to deliver active molecules to the targeted site depending on their various characteristics. However, these characteristics are dependent on the manufacturing procedures applied to prepare liposomes. Especially difficult is assurance of reproducible production in large volumes. Therefore an efficient up-scalable method for production of ... -
Modeling of glutamatergic and GABAergic drug targets in the CNS and their interactions with environmental toxicants
(Master thesis; Mastergradsoppgave, 2016-05-12)The exposure to pollutants is a serious and increasing health problem, which has been associated with increased morbidity and mortality among people. Many toxic compounds can accumulate in the environment and evidence suggests that most people have varying degrees of toxic compounds within their body. This can result in disruption of many physiological processes in the human body and the development ... -
Modelling of serotonergic receptors and molecular optimization of X-ray crystal structures of serotonin transporter and their interactions with exogenous compounds
(Master thesis; Mastergradsoppgave, 2016-05-12)The serotonin (5-hydroxytryptamine, 5-HT) receptors and transporter are in the serotonergic neurotransmission system, and believed to have a major role in pathology of depression. They are of pharmacological importance, being targeted by many nowadays antidepressants. It is therefore of great interest to understand their structural and functional properties for development of future drugs. There ... -
Modifier gene polymorphisms and influence on disease expression in FAP
(Master thesis; Mastergradsoppgave, 2009-05-20)Background: Familial adenomatous polyposis (FAP) is a hereditary autosomal dominant condition characterized by the appearance of hundreds to thousands of adenomatous polyps throughout the colon and rectum. If the condition is left untreated it will ultimately develop into colorectal cancer. Most of the articles available today concerning FAP focus on the adenomatous polyposis coli gene as this gene ... -
Modifier gene polymorphisms and influence on disease expression in HNPCC
(Master thesis; Mastergradsoppgave, 2009-05-20)Background Hereditary non-polyposis colorectal cancer(HNPCC) is an autosomal dominantly inherited predisposition to a variety of epithelial malignancies most notable colorectal and endometrial cancer. Unlike other genetic predispositions to colorectal cancer HNPCC does not present with a premalignant phenotype, which as such makes it difficult to predict when or if an affected person will present ... -
Molecular modeling of 3D structure of the oxytocin receptor. Discovery of novel oxytocin receptor agonists via molecular docking studies.
(Master thesis; Mastergradsoppgave, 2015-05-15)Oxytocin has been shown to be implicated in psychiatric diseases such as depression, anxiety disorders, autism post-traumatic stress disorder, and schizophrenia. As a result, oxytocin can be used as a potential treatment for these brain disorders. However, oxytocin is a large peptide, and is therefore unable to cross the blood brain barrier. Thus, the development of new small non-peptide drugs would ...
