Blar i tittel Mastergradsoppgaver i farmasi

Viser treff 73-92 av 294

    • Developement of mucoadhesive polymer-coated liposomes for hydration of the oral mucosa 

      Saleh, Rebwar Salar Nori (Master thesis; Mastergradsoppgave, 2013-05-18)
      Dry mucus in the oral cavity is uncomfortable for patients and can lead to other additional illnesses. Reduced or absence of saliva secretion, caused by the diseases, side effects of drugs, aging, or radiotherapy, can result in issues related to xerostomia and dental health. A system that could contribute to increased hydration of the mucus would reduce the discomfort for the patient. In addition, ...

    • Development of a homologous gene replacement approach to study ciprofloxacin resistance in clinical Escherichia coli isolates 

      Valla, Sanne Ekroll (Master thesis; Mastergradsoppgave, 2017-05-15)
      Urinary tract infections are common amongst infectious diseases in humans, and often these infections are caused by uropathogenic Escherichia coli. Effective antimicrobial treatment of infections are medical achievements that should not be taken for granted, as antimicrobial resistance has developed and causes treatments to become ineffective. Further, resistance traits can be spread between unrelated ...

    • The Development of a pharmaceutical care plan in the Scottish mental health service 

      Skarsaune, Mona (Master thesis; Mastergradsoppgave, 2008-06)
      Abstract Background Pharmaceutical care planning is increasingly seen as the most effective manner by which to deliver pharmaceutical care services to the patient. The role of the pharmacist, both specialist and generalist, is paramount, as much of the treatment in Mental Health is dependent on the effective management of the patients medication(1). Consequently, there is a need for standardised ...

    • Development of an analytical method for detection and quantification of cannabis and cannabinoid analogues in urine 

      Steinshamn, Eirin Berge (Master thesis; Mastergradsoppgave, 2010-05-20)
      Cannabis is a drug mainly consumed for its euphoric effects; users may become happy, careless and relaxed. The direct effects of cannabis in sports are performance decreasing, but cannabis can be used as a doping agent due to its relaxing properties. For these reasons, cannabinoids are prohibited in sports during competition by the World Anti-Doping Agency (WADA). In the context of the fight ...

    • Development of an in vitro model to study compromised skin: pigskin versus the Phospholipid Vesicle-based Permeation Assay 

      Fedreheim, Elena (Master thesis; Mastergradsoppgave, 2013-05-20)
      When the skin barrier is reduced, penetration of topical and transdermal drugs could potentially be enhanced and the risk of systemic effects is increased. The studies analysing penetration through intact or diseased skin are often limited by the variability in obtaining specimens of representative skin. The phospholipid vesicle-based permeation assay is an artificial barrier mimicking human stratum ...

    • Development of bioactive peptides from the parasitic hookworm as potential treatments for autoimmune diseases 

      Baumann, Markus (Master thesis; Mastergradsoppgave, 2012-06)
      Hookworms are parasitic nematodes that reside in the intestines of their host, where they feed on host blood. The large number of infected individuals and the long survival time inside the host makes it interesting to study the immunomodulatory activities of the hookworms. The excretory/secretory (ES) products are suspected to be responsible for these effects. One aim of this project was to fractionate ...

    • Development of chitosan-coated liposomes for improved therapy of vaginal infections: clotrimazole as model drug 

      Jøraholmen, May Wenche Bakke (Master thesis; Mastergradsoppgave, 2012-05)
      For many drugs the vaginal route of administration is favorable, particularly for local therapy of specific gynecological diseases such as vaginal infections. A large variety of pharmaceutical preparations have been developed for vaginal delivery, nevertheless, the efficiency of currently available dosage forms is often limited by their poor retention time at the vaginal site. Physiological changes ...

    • Development of COFRADIC HPLC system for proteomics. Sorting of N-terminal peptides 

      Banki, Maryam Ghazi Ali (Master thesis; Mastergradsoppgave, 2014-05-20)
      Proteomics, the study of the proteins constituting the proteome, has featured in the past few years as an essential tool in a number of diverse areas of therapeutic research for detection of the initial stage of a disease, for consideration of therapy response and for disintegrating fundamental pathophysiological mechanisms. Proteomics has a wide range of applications such as diabetes research, ...

    • Development of DNA Nanoparticles with Properties for Enhanced Biofilm Uptake 

      Borøy, Vegard (Mastergradsoppgave; Master thesis, 2022-05-11)
      Microbial biofilms account for up to 80% of all bacterial infections. They are described as small structural communities of bacteria which are embedded in a self-produced extracellular (EPS) matrix. This EPS matrix poses a substantial challenge for antimicrobial treatment by hindering traversal of antimicrobial agents. Nanotechnology based drug delivery systems (DDS) offer a promising solution ...

    • The development of electrospun chloramphenicol containing wound dressing 

      Murugaiah, Anjanah (Master thesis; Mastergradsoppgave, 2021-05-11)
      Wound healing is among the most complex processes in the human body that is greatly coordinated with a focus to rebuild tissue integrity and restore the skin´s protective barrier. The normal healing process is disrupted in chronic wounds, leading to delayed wound healing due to several underlying factors such as aging, obesity, and diabetes. Among chronic wounds 50 % are infected and up to 78 % of ...

    • Development of improved bendamustin-liposomes 

      Evjen, Tove Julie (Master thesis; Mastergradsoppgave, 2007-05)
      Bendamustin is an alkylating anticancer agent which is currently in routine use for the treatment of different types of cancer. The drug is very unstable in serum due to hydrolysis; the half life of the first part of the serum elimination curve is about 6-10 minutes. The rapid degradation of the drug in serum impairs its cytostatic action within a short period of time, and frequent application of ...

    • Development of liposomal curcumin for vaginal drug delivery 

      Hussain, Haider (Master thesis; Mastergradsoppgave, 2010-06-16)
      Curcumin (I), demethoxy curcumin (II) and bisdemethoxy curcumin (III) are commonly called curcuminoids, and derived products from the spice, turmeric. It has reported numerous of therapeutic activities including, anti-inflammatory, and anticancer properties. The aim of the current study was to develop a formulation which can overcome the limitation of curcumin being so poorly soluble in aqueous ...

    • Development of liposomal formulation for green tea catechins targeted for the treatment of vaginal inflammation 

      Trønnes, Johanne Naper (Master thesis; Mastergradsoppgave, 2012-05-20)
      Green tea catechins are well known for their antioxidative and anti-inflammatory properties. In this connection, catechins are thought to be potential candidates in prevention and treatment of diseases caused by oxidative damage. In addition, catechins have been shown to be effective in the treatment of genital warts. However, they exhibit low bioavailability and poor solubility, which limits their ...

    • Development of muds for improved vaginal therapy 

      Meland, Hilde-Gunn (Master thesis; Mastergradsoppgave, 2011-06-01)
      Bacterial vaginosis is a common cause of vaginitis, condition often treated with oral metronidazole. However, due to unpleasant side effects, patient compliance is often reduced. Vaginal tablet with bioadhesive properties could enable a prolonged residence time and a sustained release of a drug at the site of infection. Vagina as a drug administration site is attractive due to high surface area, ...

    • Development of orodispersible films: A new age-appropriate dosage form for children 

      Betoko, Evrard Louis Alain Brice (Master thesis; Mastergradsoppgave, 2015-05-18)
      In the recent years, governmental institutions have given incentives to the pharmaceutical industry in order to develop age-appropriate dosage forms for pediatric use. This has resulted in an interest in design of new and improved dosage form for pediatric patients. One of the many recent approaches is to take advantages of ODFs. Taste masking is a crucial step in the design of not only ODFs but all ...

    • Development of sample preparation methods for shotgun proteomic studies of white adipose tissue 

      Colnoe, Sayda (Master thesis; Mastergradsoppgave, 2016-05-13)
      Due to the lack of sunlight during the winter, people living in the arctic are unable to produce vitamin D3; hence deficiency of such vitamin is common in this part of the world. Given the geographic location of Norway, development of vitamin D deficiency is a common phenomenon. As vitamin D deficiency has become a public health issue, understanding the effects is vital for clinical implications. ...

    • Development of self-eliminating linkers for drug conjugates 

      Nergård, Silje Lillemark (Master thesis; Mastergradsoppgave, 2018-05-15)
      Newly discovered compounds through bioprospecting are screened for cytotoxicity, and many of them are found to be highly toxic. Because they are often not specifically toxic only against cancer cells, they are not further studied. These new compounds could be of further interest by temporarily masking a functional group which regulate the anticancer activity of a cytotoxic compound. This means that ...

    • Development of targeted liposome drug delivery vehicle 

      Ingebrigtsen, Sveinung Gaarden (Master thesis; Mastergradsoppgave, 2012-05-20)
      Coating of liposomes with polyethylene glycol (PEG) has proven to prolong the circulation time of liposomes in the blood stream. PEG prevents the binding of opsonins and subsequent uptake of the liposomes by mononuclear phagocytic system (MPS). The reduction in clearance of PEGylated liposomes from the circulation improve the bioavailability of the liposomes in the blood and increase the chance of ...

    • Distinct composition and pharmakokinetic profiles of smoke and smokeless tobacco products : development of an analytical method to highlight nicotine consumption as a doping agent 

      Lange, Ida Engelsen (Master thesis; Mastergradsoppgave, 2010-05-20)
      Nicotine is a pharmacological active compound found in the tobacco plant, and works as a a stimulant of the central nervous system. Evidence is presented that use of nicotine may have beneficial effects on athletes’ performance. Nicotine is known to cause weight loss and to improve mental capacity by enhancing concentration and relieving anxiety. Additionally, improved exercise endurance after ...

    • DNA uptake in mammalian cell cultures 

      Hætta, Annbjørg Susanna (Mastergradsoppgave; Master thesis, 2009-07)
      Det har lenge vært hevdet at DNA som finnes i mat er innskrenket til, og blir hurtig degradert i fordøyelsessystemet til pattedyrene. Denne antagelsen har vist seg å være riktig for majoriteten av DNA i mat som går inn i fordøyelsessystemet, men mange studier har vist at denne degraderingen ikke skjer 100 %. DNA er et stabilt molekyl som kan overleve forholdene i fordøyelsessystemet, og herfra ...