Mastergradsoppgaver i farmasi: Recent submissions

Now showing items 61-80 of 312

    • Bruk av kosttilskudd blant apotekkunder 

      Nguyen, May Nha Tran (Mastergradsoppgave; Master thesis, 2020-05-14)
      Bakgrunn Bruk av kosttilskudd er utbredt over hele verden, og apoteket representerer en salgskanal for denne varegruppen. Det finnes lite forskning om disse produktene, særlig i Norge. Kosttilskudd regnes som næringsmidler, og er dermed ikke regulert på lik linje som legemidler. Dette kan føre til uhensiktsmessig bruk, særlig blant apotekkunder. Disse kan være legemiddelbrukere, hvor en potensiell ...

    • Isolation, structure elucidation and bioactivity profiling of lyso-ornithine lipids from the marine bacterium Lacinutrix sp. 

      Jawad, Jawad (Master thesis; Mastergradsoppgave, 2021-05-11)
      From previous work, it was identified two analytes of interest, produced by Lacinutrix sp. The two analytes are iso-branched lyso-ornithine lipids with only one CH2 group differing between the two compounds, in the hydrocarbon chain (lysoC15:0 and C16:0). The bacterium was isolated from the marine sponge Halicondria sp. that was collected beside Bjørnøya, on a research cruise in 2009. The analytes ...

    • Association between the use of Proton Pump Inhibitors and Histamine-2 Receptor Antagonists and the risk of gastric cancer in Norway 

      Tran, Kenny Khang (Master thesis; Mastergradsoppgave, 2021-05-13)
      Background: The use of proton pump inhibitors (PPIs) on prescription has increased over the last decade in Norway. PPIs are an important medication in the treatment of acid related disorders such as peptic ulcer disease, gastroesophageal reflux disease and Helicobacter Pylori (H. Pylori) infection. However, many previous studies have raised concern about the potential risk of gastric cancer following ...

    • Studie av glukokortikoidreseptoren (GR) og transkripsjonsfaktoren PAX6 i linseceller under oksidativt stress 

      Mellem, Viktoria Sareussen (Mastergradsoppgave; Master thesis, 2021-05-11)
      PAX6 er en transkripsjonsfaktor som er viktig for den normale utviklingen og funksjonen til øyet. Mutasjoner i PAX6 eller langvarig bruk av glukokortikoider er assosiert med patologiske tilstander i øyet, noe som indikerer at begge faktorene er viktig for øyets normalfunksjon. Øyet utsettes for oksidativt stress, og det er tidligere rapportert at både PAX6 og glukokortikoidreseptoren (GR) i andre ...

    • Clinical Lipidomics: Effects of Vitamin D in Human Adipose Tissue 

      Chan, Sze Mang Sammy (Master thesis; Mastergradsoppgave, 2021-05-10)
      Vitamin D is vital for calcium homeostasis and skeletal health, has immunomodulatory effects and is involved in the regulation of differentiation and proliferation of many different cell types. Adipose tissue is an important metabolic organ and a major organ for vitamin D storage. Though, the role of vitamin D and its function in adipose tissue is not fully explored. This thesis applies a solvent ...

    • Molecular modelling of interactions between antipsychotic drugs and receptors mediating antipsychotic effects and important side effects 

      Issifou, Halimatu Sadia T. (Master thesis; Mastergradsoppgave, 2021-05-10)
      Dopamine and serotonin are two neurotransmitters that exert their actions through mediation of dopaminergic and serotonergic receptors respectively. The receptors in focus in the current study, are the dopamine D2 and serotonin 5-HT2A receptors. Common for both receptors is that they are class A G-protein-coupled receptors consisting of seven transmembrane helices embedded in the lipid membrane of ...

    • Network Analysis: an approach to the study of drug-drug relations. Co-medication in Norwegian elderly and severe drug-drug interactions as examples 

      Askar, Mohsen (Master thesis; Mastergradsoppgave, 2019-05-15)
      Network analysis (NA) has been used for studying many social aspects. Employing of network analysis as an approach in the field of public health, to study the relations between patients or health workers and their potential effects in many medical perspectives, took a good share of researchers’ efforts as well. Few attempts have been conducted to use network analysis to study drug-drug relations ...

    • Collateral sensitivity in clinical mecillinam resistant isolates of Escherichia coli 

      Nguyen, Tammy Tam Hoai Thi (Master thesis; Mastergradsoppgave, 2016-05-13)
      Background The rapid increase in antimicrobial resistance (AMR) has become a major threat to the successful management of infectious diseases. To counteract this global threat, development of novel treatment strategies is essential. A promising strategy may be exploiting collateral sensitivity; a phenomenon that occurs when a microorganism that has developed resistance to one antimicrobial agent, ...

    • Influence of environmental tonicity changes on lipophilic drug release from liposomes 

      Nikolaisen, Trygg Einar (Mastergradsoppgave; Master thesis, 2018-05-15)
      Introduction: Liposomes as drug delivery systems has been widely studied as a way to solubilize poorly soluble drugs, reduce side effects of chemotherapeutics and increase circulation time in vivo. Since the first descriptions of liposomes over 60 years ago, they have shown tendencies to shrink and swell when the external environment of the liposomes is altered. This phenomenon has been studied in ...

    • Topical vaginal therapy: Development of a liposomal hydrogel delivery system for epicatechin 

      Moueffaq, Sabrin (Mastergradsoppgave; Master thesis, 2018-05-15)
      Vaginal infections are common in women of all ages and proper treatment is essential. The vaginal route of administration can be considered as favourable for the local therapy of vaginal infections. There are several vaginal dosage forms currently available; however, all suffer from limitations such as leakage and limited residence time at the site of action resulting in reduced therapeutic effect. ...

    • Etikk og farmasøytisk praksis i apotek 

      Johannessen, Karen Øvrebø (Mastergradsoppgave; Master thesis, 2021-04-26)
      Etikkrådet for farmasøyter i Norge har en visjon om at alle farmasøyter skal være etisk reflekterte yrkesutøvere. Etiske dilemma oppstår når ulike verdier kommer i konflikt med hverandre og ikke kan forenes i en og samme handling. Apotekene i Norge har i de siste årene forandret seg i takt med nye lover og regler og farmasøytene har etter hvert fått utvidede oppgaver som setter andre krav til yrket. ...

    • LC-MS characterization of pigments in microalgae from different cultivation regimes 

      Stokkeland, Ingunn Møgedal (Master thesis; Mastergradsoppgave, 2019-05-15)
      <p>Background: The Artic University of Norway entered a partnership with a smelting plant to reduce the factory fume CO2-footprint by cultivation of microalgae (diatoms). The biomass produced from the microalgae is rich in lipids, proteins and pigments and can potentially function as fish feed for the aquaculture industry. Before the biomass can be utilized as e.g. fish feed, a thorough investigation ...

    • Antibiotikaforskrivning ved samfunnservervet pneumoni og KOLS-eksaserbasjon ved Universitetssykehuset Nord-Norge 

      Tøndel, Birgitte Gladsø (Master thesis; Mastergradsoppgave, 2019-05-15)
      <p>Bakgrunn: Rasjonell antibiotikaforskrivning, som i denne sammenheng vil si i henhold til Nasjonal faglig retningslinje for antibiotikabruk i sykehus, er et av de viktigste tiltakene vi har for å motvirke resistensutvikling. Forskrivning i henhold til retningslinjer er også assosiert med gunstige pasientutfall. Samfunnservervet pneumoni (community-acquired pneumonia; CAP) og kronisk obstruktiv ...

    • Docetaxel in liposomes: the effect of lipid composition on the achieved drug entrapment 

      Karlsen, Iselin (Mastergradsoppgave; Master thesis, 2018-05-15)
      INTRODUCTION: Docetaxel (DOC) is a potent anticancer drug but has several limitations such as poor solubility. The currently commercially available formulation of DOC is limited by reported serious side effects which either is attributed to the drug itself or the solvent used. Nanomedicine has been used for improving the therapeutic outcome of several drugs, but so far there are none available with ...

    • Evaluation and Late-Stage Fluorination of Small Molecule GnRH-R Antagonists 

      Rustad, Eirik André Lindeløff (Mastergradsoppgave; Master thesis, 2019-05-15)
      Alzheimer’s disease is the most common type of dementia; causing problems with memory, thinking and behaviour. The seemingly protective effect of hormone replacement therapy against Alzheimer’s disease sparked an interest in the role of the sex hormone system. Sex steroid production is dependent on gonadotropins released in the pituitary. The gonadotropin level is controlled by gonadotropin releasing ...

    • Liposomes-in-hydrogel delivery system containing resveratrol for the local treatment of vaginal infections 

      Tostrup, Mia Jonine (Mastergradsoppgave; Master thesis, 2018-05-15)
      Administering drug formulations to the vagina is a challenge since the vagina possesses “self-cleaning” features which allow trapping and rapid removing of foreign particles. Therefore, the residence time of drugs is often too short to offer a sufficient clinical effect. The aim of this project was to develop and optimize a liposomes-in-hydrogel system containing resveratrol for the local treatment ...

    • How will anonymization of simulated clinical data affect the data utility of pharmacoepidemiological studies? 

      Cheang, Chi Kei (Mastergradsoppgave; Master thesis, 2019-05-14)
      Background: The pressure to share more data and being more transparency of clinical study reports has grown and becomes an important topic in recent years. Before clinical data and clinical results can be shared they must undergo anonymization. How anonymization of clinical data affects the utility is poorly-studied, especially in pharmacoepidemiology. Objective: The aim of the study is to describe ...

    • Characterization of inhibition by vardenafil analogues of ATP-dependent transport of cGMP by the ABCC5 transporter. 

      Kuresh, Farzane (Master thesis; Mastergradsoppgave, 2015-05-27)
      Background: Clinical studies have reported overexpression of PDE5 and elevation of intracellular cyclic GMP in various types of cancer cells. ABCC5 transports intracellular cGMP out of the cells with high affinity, while PDE5 inhibitors prevent high affinity cGMP efflux by inhibiting ABCC5. Increasing intracellular cGMP levels through inhibition of PDE5 and PDE5 export activity is hypothesized ...

    • Molecular modelling of the androgen metabolising enzyme UDP-glucuronosyltransferase 2B17 

      Trane, Ingmar (Master thesis; Mastergradsoppgave, 2018-05-25)
      The enzyme UDP-glucuronosyltransferase 2B17 (UGT2B17) has a major role in androgen metabolism, being involved in the conjugation of both testosterone and its potent metabolite dihydrotestosterone. The enzyme catalyses the transfer of glucuronic acid from UDP-glucuronic acid to the lipophilic androgen substrate. As a consequence, the water solubility of the substrate is increased, and it is more ...

    • Development of orodispersible films: A new age-appropriate dosage form for children 

      Betoko, Evrard Louis Alain Brice (Master thesis; Mastergradsoppgave, 2015-05-18)
      In the recent years, governmental institutions have given incentives to the pharmaceutical industry in order to develop age-appropriate dosage forms for pediatric use. This has resulted in an interest in design of new and improved dosage form for pediatric patients. One of the many recent approaches is to take advantages of ODFs. Taste masking is a crucial step in the design of not only ODFs but all ...