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dc.contributor.authorBahls, Martin
dc.contributor.authorLorenz, Matthias W.
dc.contributor.authorDörr, Marcus
dc.contributor.authorGao, Lu
dc.contributor.authorKitagawa, Kazuo
dc.contributor.authorTuomainen, Tomi-Pekka
dc.contributor.authorAgewall, Stefan
dc.contributor.authorBerenson, Gerald
dc.contributor.authorCatapano, Alberico L.
dc.contributor.authorNorata, Guiseppe D.
dc.contributor.authorBots, Michiel L.
dc.contributor.authorvan Gilst, Wiek
dc.contributor.authorAsselbergs, Folkert W.
dc.contributor.authorBrouwers, Frank P.
dc.contributor.authorUthoff, Heiko
dc.contributor.authorSander, Dirk
dc.contributor.authorPoppert, Holger
dc.contributor.authorHecht Olsen, Michael
dc.contributor.authorEmpana, Jean Philippe
dc.contributor.authorSchminke, Ulf
dc.contributor.authorBaldassarre, Damiano
dc.contributor.authorVeglia, Fabrizio
dc.contributor.authorFranco, Oscar H.
dc.contributor.authorKavousi, Maryam
dc.contributor.authorde Groot, Eric
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorGrigore, Liliana
dc.contributor.authorPolak, Joseph F.
dc.contributor.authorRundek, Tatjana
dc.contributor.authorStehouwer, Coen D.A.
dc.contributor.authorSkilton, Michael R.
dc.contributor.authorHatzitolios, Apostolos I.
dc.contributor.authorSavopoulos, Christos
dc.contributor.authorNtaios, George
dc.contributor.authorPlichart, Matthieu
dc.contributor.authorMcLachlan, Stela
dc.contributor.authorLind, Lars
dc.contributor.authorWilleit, Peter
dc.contributor.authorSteinmetz, Helmuth
dc.contributor.authorDesvarieux, Moise
dc.contributor.authorIkram, M. Arfan
dc.contributor.authorJohnsen, Stein Harald
dc.contributor.authorSchmidt, Caroline
dc.contributor.authorWilleit, Johann
dc.contributor.authorDucimetière, Pierre
dc.contributor.authorPrice, Jackie F.
dc.contributor.authorBergström, Göran
dc.contributor.authorKauhanen, Jussi
dc.contributor.authorKiechl, Stefan
dc.contributor.authorSitzer, Matthias
dc.contributor.authorBickel, Horst
dc.contributor.authorSacco, Ralph L.
dc.contributor.authorHofman, Albert
dc.contributor.authorVölzke, Henry
dc.contributor.authorThompson, Simon G.
dc.date.accessioned2020-08-25T11:01:38Z
dc.date.available2020-08-25T11:01:38Z
dc.date.issued2019-10-16
dc.description.abstract<i>Aims</i> - Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear.<p> <p><i>Methods and results</i> - An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events.<p> <p><i>Conclusion</i> - Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in individuals with the risk of future clinical endpoints.en_US
dc.identifier.citationBahls, M., Lorenz, M.W., Dörr, M., Gao, L., Kitagawa, K., Tuomainen, T. ... Thompson SG. (2020). Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium. <i>European Journal of Preventive Cardiology (EJPC), 27</i>(3):234-243.en_US
dc.identifier.cristinIDFRIDAID 1808074
dc.identifier.doi10.1177/2047487319877078
dc.identifier.issn2047-4873
dc.identifier.issn2047-4881
dc.identifier.urihttps://hdl.handle.net/10037/19143
dc.language.isoengen_US
dc.publisherSAGE Publicationsen_US
dc.relation.journalEuropean Journal of Preventive Cardiology (EJPC)
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© The European Society of Cardiology 2019en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleProgression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortiumen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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