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dc.contributor.authorThomassen, Ivar Kristian
dc.contributor.authorMccormick-Mcpherson, Laura J
dc.contributor.authorBorisov, Sergey M.
dc.contributor.authorGhosh, Abhik
dc.date.accessioned2020-09-18T07:40:28Z
dc.date.available2020-09-18T07:40:28Z
dc.date.issued2020-05-05
dc.description.abstractSix-coordinate iridium(III) triarylcorrole derivatives, Ir[T<i>p</i>XPC)]L<sub>2</sub>, where T<i>p</i>XPC = tris(<i>para</i>-X-phenyl)corrole (X = CF<sub>3</sub>, H, Me, and OCH<sub>3</sub>) and L = pyridine (py), trimethylamine (tma), isoquinoline (isoq), 4-dimethylaminopyridine (dmap), and 4-picolinic acid (4pa), have been examined, with a view to identifying axial ligands most conducive to near-infrared phosphorescence. Disappointingly, the phosphorescence quantum yield invariably turned out to be very low, about 0.02 – 0.04% at ambient temperature, with about a two-fold increase at 77 K. Phosphorescence decay times were found to be around ~5 µs at 295 K and ~10 µs at 77 K. Fortunately, two of the Ir[T<i>p</i>CF<sub>3</sub>PC)]L<sub>2</sub> derivatives, which were tested for their ability to sensitize singlet oxygen formation, were found to do so efficiently with quantum yields Φ(<sup>1</sup>O<sub>2</sub>) = 0.71 and 0.38 for L = py and 4pa, respectively. Iridium corroles thus may hold promise as photosensitizers in photodynamic therapy (PDT). The possibility of varying the axial ligand and of attaching biotargeting groups at the axial positions makes iridium corroles particularly exciting as PDT drug candidates.en_US
dc.identifier.citationThomassen, Mccormick-Mcpherson, Borisov, Ghosh. Iridium Corroles Exhibit Weak Near-Infrared Phosphorescence but Efficiently Sensitize Singlet Oxygen Formation. Scientific Reports. 2020en_US
dc.identifier.cristinIDFRIDAID 1826461
dc.identifier.doi10.1038/s41598-020-64389-3
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/19427
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.journalScientific Reports
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/NANO2021/262229/Norway/Metallocorroles for photodynamic therapy and bioimaging//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440en_US
dc.titleIridium Corroles Exhibit Weak Near-Infrared Phosphorescence but Efficiently Sensitize Singlet Oxygen Formationen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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