Show simple item record

dc.contributor.authorFelipe Guerrero-Garzón, Jaime
dc.contributor.authorMadland, Eva
dc.contributor.authorZehl, Martin
dc.contributor.authorSingh, Madhurendra
dc.contributor.authorRezaei, Shiva
dc.contributor.authorAachmann, Finn Lillelund
dc.contributor.authorCourtade, Gaston
dc.contributor.authorUrban, Ernst
dc.contributor.authorRückert, Christian
dc.contributor.authorBusche, Tobias
dc.contributor.authorKalinowski, Jörn
dc.contributor.authorCao, Yan-Ru
dc.contributor.authorJiang, Yi
dc.contributor.authorJiang, Cheng-lin
dc.contributor.authorSelivanova, Galina
dc.contributor.authorZotchev, Sergey
dc.date.accessioned2020-11-18T10:46:20Z
dc.date.available2020-11-18T10:46:20Z
dc.date.issued2020-11-10
dc.description.abstractHeterologous expression of a biosynthesis gene cluster from <i>Amycolatopsis</i> sp. resulted in the discovery of two unique class IV lasso peptides, felipeptins A1 and A2. A mixture of felipeptins stimulated proliferation of cancer cells, while having no such effect on the normal cells. Detailed investigation revealed, that pre-treatment of cancer cells with a mixture of felipeptins resulted in downregulation of the tumor suppressor Rb, making the cancer cells to proliferate faster. Pre-treatment with felipeptins made cancer cells considerably more sensitive to the anticancer agent doxorubicin, and re-sensitized doxorubicin resistant cells to this drug. Structural characterization and binding experiments showed an interaction between felipeptins resulting in complex formation, which explains their synergistic effect. This discovery may open an alternative avenue in cancer treatment, helping to eliminate quiescent cells that often lead to cancer relapse.en_US
dc.identifier.citationFelipe Guerrero-Garzón, Madland, Zehl, Singh, Rezaei, Aachmann, Courtade, Urban, Rückert, Busche, Kalinowski, Cao, Jiang, Jiang, Selivanova, Zotchev. Class IV lasso peptides synergistically induce proliferation of cancer cells and sensitize them to doxorubicin. iScience. 2020en_US
dc.identifier.cristinIDFRIDAID 1846701
dc.identifier.doi10.1016/j.isci.2020.101785
dc.identifier.issn2589-0042
dc.identifier.urihttps://hdl.handle.net/10037/19869
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journaliScience
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FORINFRA/226244/Norway/The Norwegian NMR Platform/NNP/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BIOTEK2021/269408/Norway/DL: OXYMOD - Optimized oxidative enzyme systems for efficient conversion of lignocellulose to valuable products/OXYMOD/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.titleClass IV lasso peptides synergistically induce proliferation of cancer cells and sensitize them to doxorubicinen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record