dc.contributor.author | Rypdal, Veronika Gjertsen | |
dc.contributor.author | Glerup, Mia | |
dc.contributor.author | Songstad, Nils Tomas | |
dc.contributor.author | Bertelsen, Geir | |
dc.contributor.author | Christoffersen, Terje | |
dc.contributor.author | Arnstad, Ellen D. | |
dc.contributor.author | Aalto, Kristiina | |
dc.contributor.author | Berntson, Lillemor | |
dc.contributor.author | Fasth, Anders | |
dc.contributor.author | Herlin, Troels | |
dc.contributor.author | Ekelund, Maria | |
dc.contributor.author | Peltoniemi, Suvi | |
dc.contributor.author | Toftedal, Peter | |
dc.contributor.author | Nielsen, Susan | |
dc.contributor.author | Leinonen, Sanna | |
dc.contributor.author | Bangsgaard, Regitze | |
dc.contributor.author | Nielsen, Rasmus | |
dc.contributor.author | Rygg, Marite | |
dc.contributor.author | Nordal, Ellen | |
dc.date.accessioned | 2020-12-09T12:41:31Z | |
dc.date.available | 2020-12-09T12:41:31Z | |
dc.date.issued | 2020-08-28 | |
dc.description.abstract | <i>Purpose</i> - To assess the long-term outcome of uveitis in juvenile idiopathic arthritis (JIA).<p>
<p><i>Design</i> - Population-based, multicenter, prospective JIA cohort, with a cross-sectional assessment of JIA-associated uveitis (JIA-U) 18 years after the onset of JIA.<p>
<p><i>Participants</i> - A total of 434 patients with JIA, of whom 96 had uveitis, from defined geographic areas of Denmark, Finland, Norway, and Sweden.<p>
<p><i>Methods</i> - Patients with onset of JIA between January 1997 and June 2000 were prospectively followed for 18 years. Pediatric rheumatologists and ophthalmologists collected clinical and laboratory data.<p>
<p><i>Main Outcome Measures</i> - Cumulative incidence of uveitis and clinical characteristics, JIA and uveitis disease activity, ocular complications, visual outcome, and risk factors associated with the development of uveitis-related complications.<p>
<p><i>Results</i> - Uveitis developed in 96 (22.1%) of 434 patients with JIA. In 12 patients (2.8%), uveitis was diagnosed between 8 and 18 years of follow-up. Systemic immunosuppressive medication was more common among patients with uveitis (47/96 [49.0%]) compared with patients without uveitis (78/338 [23.1%]). Active uveitis was present in 19 of 78 patients (24.4%) at the 18-year visit. Ocular complications occurred in 31 of 80 patients (38.8%). Short duration between the onset of JIA and the diagnosis of uveitis was a risk factor for developing ocular complications (odds ratio [OR], 1.4; 95% confidence interval [CI], 1.1–1.8). Patients with a diagnosis of uveitis before the onset of JIA all developed cataract and had an OR for development of glaucoma of 31.5 (95% CI, 3.6–274). Presence of antinuclear antibodies (ANAs) was also a risk factor for developing 1 or more ocular complications (OR, 3.0; 95% CI, 1.2–7.7). Decreased visual acuity (VA) <6/12 was found in 12 of 135 eyes (8.9%) with uveitis, and 4 of 80 patients (5.0%) with JIA-U had binocular decreased VA <6/12.<p>
<p><i>Conclusions</i> - Our results suggest that uveitis screening should start immediately when the diagnosis of JIA is suspected or confirmed and be continued for more than 8 years after the diagnosis of JIA. Timely systemic immunosuppressive treatment in patients with a high risk of developing ocular complications must be considered early in the disease course to gain rapid control of ocular inflammation. | en_US |
dc.identifier.citation | Rypdal, Glerup, Songstad, Herlin, Rygg, Nordal. Uveitis in Juvenile Idiopathic Arthritis 18-Year Outcome in the Population-based Nordic Cohort Study. Ophthalmology (Rochester, Minn.). 2020 | en_US |
dc.identifier.cristinID | FRIDAID 1841529 | |
dc.identifier.doi | 10.1016/j.ophtha.2020.08.024 | |
dc.identifier.issn | 0161-6420 | |
dc.identifier.issn | 1549-4713 | |
dc.identifier.uri | https://hdl.handle.net/10037/20042 | |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | Rypdal, V.G. (2021). Prediction of unfavorable outcome in Juvenile Idiopathic Arthritis (JIA) and assessment of the long-term outcomes in JIA-associated uveitis – A prospective Nordic multicenter study of JIA from childhood to adulthood. (Doctoral thesis). <a href=https://hdl.handle.net/10037/21148>https://hdl.handle.net/10037/21148</a> | |
dc.relation.journal | Ophthalmology (Rochester, Minn.) | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2020 The Author(s) | en_US |
dc.subject | VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710 | en_US |
dc.subject | VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710 | en_US |
dc.title | Uveitis in Juvenile Idiopathic Arthritis 18-Year Outcome in the Population-based Nordic Cohort Study | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |