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dc.contributor.authorWilliamson, Adele Kim
dc.contributor.authorLeiros, Hanna-Kirsti S.
dc.date.accessioned2021-01-07T11:43:26Z
dc.date.available2021-01-07T11:43:26Z
dc.date.issued2020-05-04
dc.description.abstractDNA ligases are diverse enzymes with essential functions in replication and repair of DNA; here we review recent advances in their structure and distribution and discuss how this contributes to understanding their biological roles and technological potential. Recent high-resolution crystal structures of DNA ligases from different organisms, including DNA-bound states and reaction intermediates, have provided considerable insight into their enzymatic mechanism and substrate interactions. All cellular organisms possess at least one DNA ligase, but many species encode multiple forms some of which are modular multifunctional enzymes. New experimental evidence for participation of DNA ligases in pathways with additional DNA modifying enzymes is defining their participation in non-redundant repair processes enabling elucidation of their biological functions. Coupled with identification of a wealth of DNA ligase sequences through genomic data, our increased appreciation of the structural diversity and phylogenetic distribution of DNA ligases has the potential to uncover new biotechnological tools and provide new treatment options for bacterial pathogens.en_US
dc.identifier.citationWilliamson, Leiros. Structural insight into DNA joining: from conserved mechanisms to diverse scaffolds. Nucleic Acids Research. 2020;48(15):8225-8242en_US
dc.identifier.cristinIDFRIDAID 1855296
dc.identifier.doi10.1093/nar/gkaa307
dc.identifier.issn0305-1048
dc.identifier.issn1362-4962
dc.identifier.urihttps://hdl.handle.net/10037/20189
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalNucleic Acids Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440en_US
dc.titleStructural insight into DNA joining: from conserved mechanisms to diverse scaffoldsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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