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dc.contributor.authorHeitmann, Kim Arne
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorHopstock, Laila Arnesdatter
dc.contributor.authorStylidis, Michael
dc.contributor.authorWelde, Boye
dc.contributor.authorSchirmer, Henrik
dc.contributor.authorMorseth, Bente
dc.date.accessioned2021-01-15T09:16:21Z
dc.date.available2021-01-15T09:16:21Z
dc.date.issued2020-12-31
dc.description.abstractWhereas left atrial (LA) enlargement is an independent predictor for adverse cardiovascular events and all-cause mortality, this is regarded a physiological adaption of exercise. Paradoxically, LA size in athletes may overlap the enlargement observed in patients with cardiac pathology. Current knowledge is mainly derived from studies of athletes, and little is known about cardiac adaptations to physical activity (PA) in the general population. We explored the association between objectively measured PA and LA volume index (LAVi), and between LAVi enlargement and indices of diastolic dysfunction stratified by PA-level.<p> <p>Our study included 1573 participants from the population-based Tromsø Study (2015–16). PA was assessed with an ActiGraph wGT3X-BT accelerometer. Echocardiography was performed according to current guidelines. The associations between PA and LAVi, and between LAVi enlargement and indices of diastolic dysfunction were estimated by univariable and multivariable linear regression analyses, adjusted for sex, age, and cardiovascular risk factors.<p> <p>Our multiple adjusted analyses showed significant linear associations between PA and LAVi in ages < 70 years, and between PA and LAVi in participants with normal diastolic function. No associations were seen in ages ≥ 70 years or for participants with abnormal diastolic function. In those 40–54 years, the most active participants had larger LAVi (4.45 mL/m<sup>2</sup>, p = 0.016) than the least active. LAVi enlargement was only associated with indices of diastolic dysfunction in the most inactive participants.<p> <p>In conclusion, higher levels of PA associate with greater LAVi in participants < 70 years with normal diastolic function. LAVi enlargement is only associated with diastolic dysfunction in the most inactive participants.en_US
dc.identifier.citationHeitmann, Løchen, Hopstock, Stylidis, Welde, Schirmer, Morseth. Cross-sectional associations between accelerometry-measured physical activity, left atrial size, and indices of left ventricular diastolic dysfunction: The Tromsø Study. Preventive Medicine Reports. 2021en_US
dc.identifier.cristinIDFRIDAID 1864567
dc.identifier.doi10.1016/j.pmedr.2020.101290
dc.identifier.issn2211-3355
dc.identifier.urihttps://hdl.handle.net/10037/20289
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofHeitmann, K.A. (2023). Physical activity and the structure and function of the left side of the heart. (Doctoral thesis). <a href=https://hdl.handle.net/10037/28634>https://hdl.handle.net/10037/28634</a>.
dc.relation.journalPreventive Medicine Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleCross-sectional associations between accelerometry-measured physical activity, left atrial size, and indices of left ventricular diastolic dysfunction: The Tromsø Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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