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dc.contributor.authorMajonga, Edith D.
dc.contributor.authorChiesa, Scott T.
dc.contributor.authorMcHough, Grace
dc.contributor.authorMujuru, Hilda
dc.contributor.authorNathoo, Kusum
dc.contributor.authorOdland, Jon Øyvind
dc.contributor.authorKaski, Juan Pablo
dc.contributor.authorFerrand, Rashida A.
dc.date.accessioned2021-01-29T13:23:55Z
dc.date.available2021-01-29T13:23:55Z
dc.date.issued2020-04
dc.description.abstractIncreased carotid intima-media thickness (cIMT) is reported in both adults and children with human immunodeficiency virus (HIV) in high income settings and is associated with an increased risk of cardiovascular disease, but data from sub-Saharan Africa is lacking.<p> <p>We assessed cIMT using ultrasound in perinatally HIV-infected children aged 6 to 16 years taking antiretroviral therapy (ART) for ≥6 months compared with HIV-uninfected controls in Harare, Zimbabwe. Groups were compared using unpaired t test and potential predictors of cIMT were assessed using multiple linear regression.<p> <p>A total of 117 participants with HIV, of whom 55 (45%) were female and 75 healthy uninfected controls were included. Participants with HIV were younger than uninfected controls, 10.7 (2.4) years versus 11.9 (2.6) years (P = .001). Mean cIMT was 0.40 (0.05) mm in those with HIV versus 0.40 (0.04) mm in healthy controls (P = .377). There was no association between cluster of differentiation 4 count, HIV viral load, and duration on ART and cIMT.<p> <p>Children with HIV taking ART have similar cIMT to uninfected children. Increasing numbers of children with HIV are reaching adulthood and longitudinal studies to assess the effect of long-term HIV and ART on vascular changes are required.en_US
dc.identifier.citationMajonga ED, Chiesa, McHough, Mujuru H, Nathoo K, Odland j, Kaski JP, Ferrand RA. Carotid intima media thickness in older childrenand adolescents with HIV taking antiretroviraltherapy. Medicine. 2020en_US
dc.identifier.cristinIDFRIDAID 1879561
dc.identifier.doi10.1097/MD.0000000000019554
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.urihttps://hdl.handle.net/10037/20509
dc.language.isoengen_US
dc.publisherWolters Kluwer Healthen_US
dc.relation.journalMedicine
dc.relation.projectIDNorges forskningsråd: 234424en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleCarotid intima media thickness in older childrenand adolescents with HIV taking antiretroviraltherapyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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