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dc.contributor.authorHåheim, Brage
dc.contributor.authorKondratyev, Timofey
dc.contributor.authorDietrichs, Erik Sveberg
dc.contributor.authorTveita, Torkjel
dc.date.accessioned2021-01-29T13:31:27Z
dc.date.available2021-01-29T13:31:27Z
dc.date.issued2020-11-12
dc.description.abstractRewarming from hypothermia is often challenged by coexisting cardiac dysfunction, depressed organ blood flow (OBF), and increased systemic vascular resistance. Previous research shows cardiovascular inotropic support and vasodilation during rewarming to elevate cardiac output (CO). The present study aims to compare the effects of inodilatation by levosimendan (LS) and vasodilation by nitroprusside (SNP) on OBF and global oxygen transport during rewarming from hypothermia. We used an in vivo experimental rat model of 4 h 15°C hypothermia and rewarming. A stable isotope-labeled microsphere technique was used to determine OBF. Cardiac and arterial pressures were monitored with fluid-filled pressure catheters, and CO was measured by thermodilution. Two groups were treated with either LS (n = 7) or SNP (n = 7) during the last hour of hypothermia and throughout rewarming. Two groups served as hypothermic (n = 7) and normothermic (n = 6) controls. All hypothermia groups had significantly reduced CO, oxygen delivery, and OBF after rewarming compared to their baseline values. After rewarming, LS had elevated CO significantly more than SNP (66.57 ± 5.6/+30% vs. 54.48 ± 5.2/+14%) compared to the control group (47.22 ± 3.9), but their ability to cause elevation of brain blood flow (BBF) was the same (0.554 ± 0.180/+81 vs. 0.535 ± 0.208/+75%) compared to the control group (0.305 ± 0.101). We interpret the vasodilator properties of LS and SNP to be the primary source to increase organ blood flow, superior to the increase in CO.en_US
dc.identifier.citationHåheim, Kondratyev T.V., Dietrichs, Tveita. Comparison between two pharmacologic strategies to alleviate rewarming shock: vasodilation vs. inodilation. Frontiers in medicine. 2020en_US
dc.identifier.cristinIDFRIDAID 1837234
dc.identifier.doi10.3389/fmed.2020.566388
dc.identifier.issn2296-858X
dc.identifier.urihttps://hdl.handle.net/10037/20510
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in medicine
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/?/?/?/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleComparison between two pharmacologic strategies to alleviate rewarming shock: vasodilation vs. inodilationen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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