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dc.contributor.authorFlorholmen, Jon
dc.contributor.authorJohnsen, Kay-Martin
dc.contributor.authorMeyer, Renate
dc.contributor.authorOlsen, Trine
dc.contributor.authorMoe, Øystein Kittel
dc.contributor.authorTandberg, Petter
dc.contributor.authorGundersen, Mona Dixon
dc.contributor.authorKvamme, Jan-Magnus
dc.contributor.authorJohnsen, Knut
dc.contributor.authorLøitegård, Terje
dc.contributor.authorRaschpichler, Gabriele
dc.contributor.authorVold, Cecilia
dc.contributor.authorSørbye, Sveinung
dc.contributor.authorGoll, Rasmus
dc.date.accessioned2021-02-26T09:38:17Z
dc.date.available2021-02-26T09:38:17Z
dc.date.issued2020-10-02
dc.description.abstract<i>Background</i> - There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim of this study was to explore a comprehensive data set to identify and validate predictors of clinical outcome in the first year following diagnosis.<p> <p><i>Methods</i> - Treatment naive-patients with ulcerative colitis were included at time of initial diagnosis from 2004 to 2014, followed by a validation study from 2014 to 2018. Patients were treated according to clinical guidelines following a standard step-up regime. Patients were categorized according to the treatment level necessary to achieve clinical remission: mild, moderate and severe. The biopsies were assessed by Robarts histopathology index (RHI) and TNF gene transcripts.<p> <p><i>Results</i> - We included 66 patients in the calibration cohort and 89 patients in the validation. Mucosal TNF transcripts showed high test reliability for predicting severe outcome in UC. When combined with histological activity (RHI) scores the test improved its diagnostic reliability. Based on the cut-off values of mucosal TNF and RHI scores from the calibration cohort, the combined test had still high reliability in the validation cohort (specificity 0.99, sensitivity 0.44, PPV 0.89, NPV 0.87) and a diagnostic odds-ratio (DOR) of 54.<p> <p><i>Conclusions</i> - The combined test using TNF transcript and histological score at debut of UC can predict severe outcome and the need for anti-TNF therapy with a high level of precision. These validated data may be of great clinical utility and contribute to a personalized medical approach with the possibility of top-down treatment for selected patients.en_US
dc.identifier.citationFlorholmen, Johnsen, Meyer, Olsen, Moe, Tandberg, Gundersen, Kvamme, Johnsen, Løitegård, Raschpichler, Vold C, Sørbye, Goll. Discovery and validation of mucosal TNF expression combined with histological score-a biomarker for personalized treatment in ulcerative colitis. BMC Gastroenterology. 2020;20(1)
dc.identifier.cristinIDFRIDAID 1878963
dc.identifier.doi10.1186/s12876-020-01447-0
dc.identifier.issn1471-230X
dc.identifier.urihttps://hdl.handle.net/10037/20609
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.ispartofJohnsen, K-M. (2024). Towards personalized medicine in ulcerative colitis. Long-term follow-up after biological treatment and prediction of clinical outcomes. (Doctoral thesis). Available at: <a href=https://hdl.handle.net/10037/33602>https://hdl.handle.net/10037/33602</a>.
dc.relation.journalBMC Gastroenterology
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleDiscovery and validation of mucosal TNF expression combined with histological score-a biomarker for personalized treatment in ulcerative colitisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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