Show simple item record

dc.contributor.authorMoens, Ugo
dc.contributor.authorPrezioso, Carla
dc.contributor.authorPietropaolo, Valeria
dc.date.accessioned2021-04-26T07:15:27Z
dc.date.available2021-04-26T07:15:27Z
dc.date.issued2020-12-07
dc.description.abstractThe genomes of polyomaviruses are characterized by their tripartite organization with an early region, a late region and a noncoding control region (NCCR). The early region encodes proteins involved in replication and transcription of the viral genome, while expression of the late region generates the capsid proteins. Transcription regulatory sequences for expression of the early and late genes, as well as the origin of replication are encompassed in the NCCR. Cell tropism of polyomaviruses not only depends on the appropriate receptors on the host cell, but cell-specific expression of the viral genes is also governed by the NCCR. Thus far, 15 polyomaviruses have been isolated from humans, though it remains to be established whether all of them are genuine human polyomaviruses (HPyVs). The sequences of the NCCR of these HPyVs show high genetic variability and have been best studied in the human polyomaviruses BK and JC. Rearranged NCCRs in BKPyV and JCPyV, the first HPyVs to be discovered approximately 30 years ago, have been associated with the pathogenic properties of these viruses in nephropathy and progressive multifocal leukoencephalopathy, respectively. Since 2007, thirteen novel PyVs have been isolated from humans: KIPyV, WUPyV, MCPyV, HPyV6, HPyV7, TSPyV, HPyV9, HPyV10, STLPyV, HPyV12, NJPyV, LIPyV and QPyV. This review describes all NCCR variants of the new HPyVs that have been reported in the literature and discusses the possible consequences of NCCR diversity in terms of promoter strength, putative transcription factor binding sites and possible association with diseases.en_US
dc.identifier.citationMoens, Prezioso, Pietropaolo. Genetic Diversity of the Noncoding Control Region of the Novel Human Polyomaviruses. Viruses. 2020;12(12)en_US
dc.identifier.cristinIDFRIDAID 1866910
dc.identifier.doi10.3390/v12121406
dc.identifier.issn1999-4915
dc.identifier.urihttps://hdl.handle.net/10037/21039
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalViruses
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleGenetic Diversity of the Noncoding Control Region of the Novel Human Polyomavirusesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record