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dc.contributor.authorBerginström, Nils
dc.contributor.authorNordström, Peter
dc.contributor.authorNyberg, Lars
dc.contributor.authorNordström, Anna Hava
dc.date.accessioned2021-04-27T10:47:06Z
dc.date.available2021-04-27T10:47:06Z
dc.date.issued2020-02-09
dc.description.abstractObjective: To examine the prevalence of white matter hyperintensities (WMHs) in patients with traumatic brain injury (TBI) as compared to healthy controls, and to investigate whether there is an association between WMH lesion burden and performance on neuropsychological tests in patients with TBI.<p> <p>Methods: A total of 59 patients with TBI and 27 age- and gender-matched healthy controls underwent thorough neuropsychological testing and magnetic resonance imaging. The quantification of WMH lesions was performed using the fully automated Lesion Segmentation Tool.<p> <p>Results: WMH lesions were more common in patients with TBI than in healthy controls (p = .032), and increased with higher TBI severity (p = .025). Linear regressions showed that WMH lesions in patients with TBI were not related to performance on any neuropsychological tests (p > .05 for all). However, a negative relationship between number of WMH lesions in patients with TBI and self-assessed fatigue was found (r = – 0.33, p = .026).<p> <p>Conclusion: WMH lesions are more common in patients with TBI than in healthy controls, and WMH lesions burden increases with TBI severity. These lesions could not explain decreased cognitive functioning in patients with TBI but did relate to decreased self-assessment of fatigue after TBI.en_US
dc.identifier.citationBerginström N, Nordström P, Nyberg L, Nordström AH. White matter hyperintensities increases with traumatic brain injury severity: associations to neuropsychological performance and fatigue. Brain Injury. 2020;34(3):415-420en_US
dc.identifier.cristinIDFRIDAID 1811245
dc.identifier.doi10.1080/02699052.2020.1725124
dc.identifier.issn0269-9052
dc.identifier.issn1362-301X
dc.identifier.urihttps://hdl.handle.net/10037/21070
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalBrain Injury
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleWhite matter hyperintensities increases with traumatic brain injury severity: associations to neuropsychological performance and fatigueen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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