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dc.contributor.authorLofterød, Trygve
dc.contributor.authorFrydenberg, Hanne
dc.contributor.authorFlote, Vidar Gordon
dc.contributor.authorEggen, Anne Elise
dc.contributor.authorMcTiernan, A
dc.contributor.authorMortensen, Elin Synnøve
dc.contributor.authorAkslen, Lars A.
dc.contributor.authorReitan, J. B.
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorInger, Thune
dc.date.accessioned2021-04-28T07:43:12Z
dc.date.available2021-04-28T07:43:12Z
dc.date.issued2020-05-20
dc.description.abstract<i>Purpose</i> - Whether an unfavorable lifestyle not only affects breast cancer risk, but also influences age at onset of breast cancer and survival, is under debate.<br><br> <i>Methods</i> - In a population-based cohort, the Energy Balance and Breast Cancer Aspects throughout life (EBBA-Life) study, a total of 17,145 women were included. During follow-up, 574 women developed invasive breast cancer. Breast cancer cases were followed for an additional 9.1 years. Detailed medical records were obtained. Cox’s proportional hazard regression models were used to study the association between pre-diagnostic lifestyle factors (weight, physical activity, alcohol use, smoking, and hypertension), breast cancer risk, age at diagnosis, and survival.<br><br> <i>Results</i> - At study entry, 34.3% of the participating women were overweight and 30.7% were physically inactive. Mean age at breast cancer diagnosis was 58.0 years, and 78.9% of the tumors were estrogen receptor positive. Among menopausal women who did not use hormone therapy and had an unfavorable lifestyle (3–5 unfavorable factors), compared with women who had a favorable lifestyle, we observed a twofold higher risk for postmenopausal breast cancer (hazard ratio [HR] 2.13, 95% confidence interval [CI] 1.23–3.69), and they were 3.4 years younger at diagnosis (64.8 versus 68.2 years, <i>P</i> = 0.032). Breast cancer patients with an unfavorable lifestyle, compared with patients with a favorable lifestyle, had almost a two times higher overall mortality risk (HR 1.96, 95% CI 1.01–3.80).<br><br> <i>Conclusions</i> - Our study supports a healthy lifestyle improving breast cancer prevention, postponing onset of disease, and extending life expectancy among breast cancer patients.en_US
dc.identifier.citationLofterød T, Frydenberg H, Flote VG, Eggen AE, McTiernan A, Mortensen E, Akslen LA, Reitan JB, Wilsgaard T, Inger. Exploring the effects of lifestyle on breast cancer risk, age at diagnosis, and survival: the EBBA-Life study. Breast Cancer Research and Treatment. 2020;182(1):215-227en_US
dc.identifier.cristinIDFRIDAID 1873446
dc.identifier.doi10.1007/s10549-020-05679-2
dc.identifier.issn0167-6806
dc.identifier.issn1573-7217
dc.identifier.urihttps://hdl.handle.net/10037/21081
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalBreast Cancer Research and Treatment
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleExploring the effects of lifestyle on breast cancer risk, age at diagnosis, and survival: the EBBA-Life studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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