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dc.contributor.authorEriksen, Bjørn Odvar
dc.contributor.authorPálsson, Runólfur
dc.contributor.authorEbert, Natalie
dc.contributor.authorMelsom, Toralf
dc.contributor.authorvan der Giet, Markus
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorIndridasson, Olafur S.
dc.contributor.authorInker, Lesley A.
dc.contributor.authorJenssen, Trond Geir
dc.contributor.authorLevey, Andrew S.
dc.contributor.authorSolbu, Marit Dahl
dc.contributor.authorTighiouart, Hocine
dc.contributor.authorSchaeffner, Elke
dc.date.accessioned2021-06-09T06:42:00Z
dc.date.available2021-06-09T06:42:00Z
dc.date.issued2020-07
dc.description.abstract<i>Background</i> - Population mean GFR is lower in older age, but it is unknown whether healthy aging is associated with preserved rather than lower GFR in some individuals.<br><br> <i>Methods</i> - We investigated the cross-sectional association between measured GFR, age, and health in persons aged 50–97 years in the general population through a meta-analysis of iohexol clearance measurements in three large European population-based cohorts. We defined a healthy person as having no major chronic disease or risk factors for CKD and all others as unhealthy. We used a generalized additive model to study GFR distribution by age according to health status.<br><br> <i>Results</i> - There were 935 (22%) GFR measurements in persons who were healthy and 3274 (78%) in persons who were unhealthy. The mean GFR was lower in older age by −0.72 ml/min per 1.73 m2 per year (95% confidence interval [95% CI], −0.96 to −0.48) for men who were healthy versus −1.03 ml/min per 1.73 m2 per year (95% CI, −1.25 to −0.80) for men who were unhealthy, and by −0.92 ml/min per 1.73 m2 per year (95% CI, −1.14 to −0.70) for women who were healthy versus −1.22 ml/min per 1.73 m2 per year (95% CI, −1.43 to −1.02) for women who were unhealthy. For healthy and unhealthy people of both sexes, both the 97.5th and 2.5th GFR percentiles exhibited a negative linear association with age.<br><br> <i>Conclusions</i> - Healthy aging is associated with a higher mean GFR compared with unhealthy aging. However, both the mean and 97.5 percentiles of the GFR distribution are lower in older persons who are healthy than in middle-aged persons who are healthy. This suggests that healthy aging is not associated with preserved GFR in old age.en_US
dc.identifier.citationEriksen, Pálsson, Ebert, Melsom, van der Giet, Gudnason, Indridasson, Inker, Jenssen, Levey, Solbu, Tighiouart, Schaeffner. GFR in healthy aging: An individual participant data meta-analysis of iohexol clearance in european population-based cohorts. Journal of the American Society of Nephrology. 2020;31(7):1602-1615en_US
dc.identifier.cristinIDFRIDAID 1877619
dc.identifier.doi10.1681/ASN.2020020151
dc.identifier.issn1046-6673
dc.identifier.issn1533-3450
dc.identifier.urihttps://hdl.handle.net/10037/21374
dc.language.isoengen_US
dc.publisherAmerican Society of Nephrologyen_US
dc.relation.journalJournal of the American Society of Nephrology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright © 2020 by the American Society of Nephrologyen_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleGFR in healthy aging: An individual participant data meta-analysis of iohexol clearance in european population-based cohortsen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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