dc.contributor.author | Odida, Michael | |
dc.contributor.author | Weiderpass, Elisabete | |
dc.contributor.author | de Sanjosé, Silvia | |
dc.contributor.author | Quint, Wim | |
dc.contributor.author | Bosch, Xavier F. | |
dc.contributor.author | Klaustermeier, Joellen | |
dc.date.accessioned | 2009-09-30T12:37:34Z | |
dc.date.available | 2009-09-30T12:37:34Z | |
dc.date.issued | 2008-06-24 | |
dc.description.abstract | Background: We conducted a study aiming to describe Human Papillomavirus (HPV) type
distribution in invasive cervical carcinoma in Uganda.
<br>
Methods: 191 archival cervical carcinoma samples diagnosed in the Department of Pathology,
Makerere University in Kampala between 1968 and 1992 were analysed using a sensitive PCRReverse
Hybridization Line Probe Assay.
<br>
Results: Out of the 186 cases of confirmed invasive cervical cancer in the study paraffin blocks,
114 were positive for HPV DNA. Specific HPV genotypes were identifiable in 109 cases: HPV 16,
18, 31, 35, 39, 44, 45, 51, 52 and 70. These occurred as single infections in 105 cases (96.3%) and
as multiple infections in 4 cases (3.7%). HPV 16 or 18 accounted for 80% (84/105) of cases with
single infection.
<br>
Conclusion: The results of this study confirm the role of HPV 16 and 18 in cervical cancer
pathogenesis in the Ugandan population. The results suggest that the currently available HPV
vaccines against HPV 16 and 18 could possibly prevent the majority of invasive cervical cancers in
Uganda. | en |
dc.format.extent | 266376 bytes | |
dc.format.mimetype | application/pdf | |
dc.identifier.citation | BMC Infectious Diseases 2008, 8:85 | en |
dc.identifier.uri | https://hdl.handle.net/10037/2147 | |
dc.identifier.urn | URN:NBN:no-uit_munin_1898 | |
dc.language.iso | eng | en |
dc.publisher | BioMed Central | en |
dc.rights.accessRights | openAccess | |
dc.subject | VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gynecology and obstetrics: 756 | en |
dc.subject | VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 | en |
dc.title | Human Papillomavirus type distribution in invasive cervical cancer in Uganda | en |
dc.type | Journal article | en |
dc.type | Tidsskriftartikkel | en |
dc.type | Peer reviewed | en |