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dc.contributor.authorMatta, Michèle
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorBiessy, Carine
dc.contributor.authorCasagrande, Corinne
dc.contributor.authorYammine, Sahar
dc.contributor.authorFournier, Agnès
dc.contributor.authorOlsen, Karina Standahl
dc.contributor.authorLukic, Marco
dc.contributor.authorGram, Inger Torhild
dc.contributor.authorArdanaz, Eva
dc.contributor.authorSánchez, Maria-José
dc.contributor.authorDossus, Laure
dc.contributor.authorFortner, Renée T.
dc.contributor.authorSrour, Bernard
dc.contributor.authorJannasch, Franziska
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorAmiano, Pilar
dc.contributor.authorAgudo, Antonio
dc.contributor.authorColorado-Yohar, Sandra
dc.contributor.authorGuirós, J. Ramón
dc.contributor.authorTumino, Rosario
dc.contributor.authorPanico, Salvatore
dc.contributor.authorMasala, Giovanna
dc.contributor.authorPala, Valeria
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOlsen, Anja
dc.contributor.authorDahm, Christina C.
dc.contributor.authorRosendahl, Ann H.
dc.contributor.authorBorgquist, Signe
dc.contributor.authorWennberg, Maria
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorAune, Dagfinn
dc.contributor.authorSchmidt, Julie
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorChajes, Veronique
dc.contributor.authorGunter, Marc J.
dc.contributor.authorMurphy, Neil
dc.date.accessioned2021-07-02T13:56:32Z
dc.date.available2021-07-02T13:56:32Z
dc.date.issued2021-03-30
dc.description.abstractBackground - Trans fatty acids (TFAs) have been hypothesised to influence breast cancer risk. However, relatively few prospective studies have examined this relationship, and well-powered analyses according to hormone receptor-defined molecular subtypes, menopausal status, and body size have rarely been conducted.<p> <p>Methods - In the European Prospective Investigation into Cancer and Nutrition (EPIC), we investigated the associations between dietary intakes of TFAs (industrial trans fatty acids [ITFAs] and ruminant trans fatty acids [RTFAs]) and breast cancer risk among 318,607 women. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusted for other breast cancer risk factors.<p> <p>Results - After a median follow-up of 8.1 years, 13,241 breast cancer cases occurred. In the multivariable-adjusted model, higher total ITFA intake was associated with elevated breast cancer risk (HR for highest vs lowest quintile, 1.14, 95% CI 1.06–1.23; P trend = 0.001). A similar positive association was found between intake of elaidic acid, the predominant ITFA, and breast cancer risk (HR for highest vs lowest quintile, 1.14, 95% CI 1.06–1.23; P trend = 0.001). Intake of total RTFAs was also associated with higher breast cancer risk (HR for highest vs lowest quintile, 1.09, 95% CI 1.01–1.17; P trend = 0.015). For individual RTFAs, we found positive associations with breast cancer risk for dietary intakes of two strongly correlated fatty acids (Spearman correlation r = 0.77), conjugated linoleic acid (HR for highest vs lowest quintile, 1.11, 95% CI 1.03–1.20; P trend = 0.001) and palmitelaidic acid (HR for highest vs lowest quintile, 1.08, 95% CI 1.01–1.16; P trend = 0.028). Similar associations were found for total ITFAs and RTFAs with breast cancer risk according to menopausal status, body mass index, and breast cancer subtypes.<p> <p>Conclusions - These results support the hypothesis that higher dietary intakes of ITFAs, in particular elaidic acid, are associated with elevated breast cancer risk. Due to the high correlation between conjugated linoleic acid and palmitelaidic acid, we were unable to disentangle the positive associations found for these fatty acids with breast cancer risk. Further mechanistic studies are needed to identify biological pathways that may underlie these associations.en_US
dc.identifier.citationMatta, Huybrechts, Biessy, Casagrande, Yammine, Fournier, Olsen, Lukic, Gram, Ardanaz, Sánchez, Dossus, Fortner, Srour, Jannasch, Schulze, Amiano, Agudo, Colorado-Yohar, Guirós, Tumino, Panico, Masala, Pala, Sacerdote, Tjønneland, Olsen, Dahm, Rosendahl, Borgquist, Wennberg, Heath, Aune, Schmidt, Weiderpass, Chajes, Gunter, Murphy. Dietary intake of trans fatty acids and breast cancer risk in 9 European countries. BMC Medicine. 2021;19en_US
dc.identifier.cristinIDFRIDAID 1916010
dc.identifier.doi10.1186/s12916-021-01952-3
dc.identifier.issn1741-7015
dc.identifier.urihttps://hdl.handle.net/10037/21707
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleDietary intake of trans fatty acids and breast cancer risk in 9 European countriesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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