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dc.contributor.authorArkteg, Christian Børde
dc.contributor.authorSørbye, Sveinung Wergeland
dc.contributor.authorRiis, Lene Buhl
dc.contributor.authorDalen, Stig Manfred
dc.contributor.authorFlorholmen, Jon
dc.contributor.authorGoll, Rasmus
dc.date.accessioned2021-07-05T11:28:06Z
dc.date.available2021-07-05T11:28:06Z
dc.date.issued2021-03-08
dc.description.abstractBackground - Histological evaluation of ulcerative colitis (UC) patients has been debated ever since the first description of the disease and its role in follow-up has never been fully established. Recent evidence suggests an added benefit in accuracy when evaluating if the patient is in remission. Unfortunately, there are several different histological indices, and it is difficult to compare outcomes where different scores are applied. Histopathological evaluation is prone to subjective biases, despite the use of indices. In addition, these indices are developed by expert IBD pathologist, but applied at large, by general pathologist. Therefore, we evaluated the three most applied histological indices for UC on samples from patients in remission to compare test qualities and estimate their usefulness to identify remission by both general and GI specialized pathologist.<p> <p>Method - Mucosal biopsies from 41 UC patients in clinical and endoscopic remission were collected as part of a larger study on UC. Three pathologists blinded to the patients’ clinical status evaluated them using Geboes score (GS), Nancy Index (NI) and Robarts Histopathological Index (RHI). We calculated the agreement between the pathologists using Inter-class correlation (ICC) and visualized it with ICC-plots and Bland-Altman plots. Association between clinical factors and histological category were analysed by Fisher’s exact test.<p> <p>Results - The ICC value for GS, RHI and NI were 0.85, 0.73 and 0.70 respectively. The limits of agreement were ±6.1, ±4.0 and ±1.4, for GS, RHI and NI, respectively. Mayo endoscopic subgrade and UC clinical score did not show association with any histological scores. Despite clinical and endoscopic remission 7–35% of the patients displayed histological inflammation on a level classified as active disease, depending on the index and cut-off.<p> <p>Conclusion - A substantial amount of UC patients in clinical and endoscopic remission display inflammation on a histological level, but the ability to classify these patients accurately and consistently could be improved.en_US
dc.identifier.citationArkteg, C.B., Sørbye, S.W., Riis, L.B., Dalen, S.M., Florholmen, J. & Goll, R. (2021). Real-life evaluation of histologic scores for Ulcerative Colitis in remission. <i>PloS ONE, 16</i>(3), e0248224.
dc.identifier.cristinIDFRIDAID 1901517
dc.identifier.doi10.1371/journal.pone.0248224
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/21739
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofArkteg, C.B. (2021). When is remission remission? Elucidating the remission state in Ulcerative Colitis: a multimodal exploration. (Doctoral thesis). <a href=https://hdl.handle.net/10037/22610>https://hdl.handle.net/10037/22610</a>
dc.relation.journalPLOS ONE
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleReal-life evaluation of histologic scores for Ulcerative Colitis in remissionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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