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dc.contributor.authorLunde, Tracy Munthali
dc.contributor.authorHjerde, Erik
dc.contributor.authorAl-Haroni, Mohammed
dc.date.accessioned2021-07-08T08:10:16Z
dc.date.available2021-07-08T08:10:16Z
dc.date.issued2021-03-15
dc.description.abstract<i>Background</i>: The Tn<i>916</i>-Tn<i>1545</i> family of Integrative Conjugative Elements (ICE) are mobile genetic elements (MGEs) that play a role in the spread of antibiotic resistance genes. The Tn<i>916</i> harbors the tetracycline resistance gene <i>tet</i>(M) and it has been reported in various bacterial species. The increase in the levels of tetracycline resistance among oral streptococci is of great concern primarily due to the abundance of these species in the oral cavity and their ability to act as reservoirs for antibiotic resistance genes.<br><br> <i>Methods</i>: In the current study, we screened 100 Norwegian clinical oral streptococcal isolates for the presence and diversity of the Tn<i>916</i>-Tn<i>1545</i> family. In addition, we investigated the transferability the elements, and the associated transfer frequencies.<br><br> <i>Results</i>: We observed that 21 isolates harboured the Tn916-Tn1545 family and that two of these elements were the novel Tn<i>6815</i> and Tn<i>6816</i>. The most prevalent member of the Tn<i>916</i> -Tn<i>1545</i> family observed in the Norwegian clinical oral streptococcal isolates was the wild type Tn<i>916</i>.<br><br> <i>Conclusion</i>: The detection of other members of this family of ICE and varying transfer frequencies suggests high versatility of the Tn<i>916</i> element in oral streptococci in Norway.en_US
dc.identifier.citationLunde T, Hjerde e, Al-Haroni M. Prevalence, diversity and transferability of the Tn916-Tn1545 family ICE in oral streptococci. Journal of Oral Microbiology. 2021;13en_US
dc.identifier.cristinIDFRIDAID 1898482
dc.identifier.doi10.1080/20002297.2021.1896874
dc.identifier.issn2000-2297
dc.identifier.urihttps://hdl.handle.net/10037/21833
dc.language.isoengen_US
dc.publisherTaylor & Francis Open Accessen_US
dc.relation.ispartofLunde, T.M. (2022). Antibiotic Resistance in Oral Streptococci: The prevalence, diversity, stability, and fitness cost of Tn916 -Tn1545 family in oral streptococcal isolates. (Doctoral thesis). <a href=https://hdl.handle.net/10037/24192>https://hdl.handle.net/10037/24192</a>.
dc.relation.journalJournal of Oral Microbiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Clinical dentistry disciplines: 830en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk odontologiske fag: 830en_US
dc.titlePrevalence, diversity and transferability of the Tn916-Tn1545 family ICE in oral streptococcien_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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