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dc.contributor.authorPrezioso, Carla
dc.contributor.authorVan Ghelue, Marijke
dc.contributor.authorMoens, Ugo
dc.contributor.authorPietropaolo, Valeria
dc.date.accessioned2021-07-08T09:15:28Z
dc.date.available2021-07-08T09:15:28Z
dc.date.issued2021-01-22
dc.description.abstractBackground - Human polyomavirus 6 (HPyV6) and HPyV7 are two of the novel polyomaviruses that were originally detected in non-diseased skin. Serological studies have shown that these viruses are ubiquitous in the healthy adult population with seroprevalence up to 88% for HPyV6 and 72% for HPyV7. Both viruses are associated with pruritic skin eruption in immunocompromised patients, but a role with other diseases in immunoincompetent patients or malignancies has not been established.<p> <p>Methods - PCR was used to determine the presence of HPyV6 and HPyV7 DNA in urine samples from systemic lupus erythematosus (n = 73), multiple sclerosis (n = 50), psoriasis vulgaris (n = 15), arthritic psoriasis (n = 15) and HIV-positive patients (n = 66). In addition, urine from pregnant women (n = 47) and healthy blood donors (n = 20) was investigated.<p> <p>Results - HPyV6 DNA was detected in 21 (28.8%) of the urine specimens from SLE patients, in 6 (9.1%) of the urine samples from the HIV-positive cohort, and in 19 (40.4%) samples from pregnant women. HPyV7 DNA was only found in 6 (8.2%) of the urine specimens from SLE patients and in 4 (8.5%) samples from pregnant women. No HPyV6 and HPyV7 viruria was detected in the urine samples from the other patients.<p> <p>Conclusions - HPyV6, and to a lesser extend HPyV7, viruria seems to be common in SLE and HIV-positive patients, and pregnant women. Whether these viruses are of clinical relevance in these patients is not known.en_US
dc.identifier.citationPrezioso C, Van Ghelue GM, Moens u, Pietropaolo V. HPyV6 and HPyV7 in urine from immunocompromised patients. Virology Journal. 2021;18(24)
dc.identifier.cristinIDFRIDAID 1877050
dc.identifier.doi10.1186/s12985-021-01496-1
dc.identifier.issn1743-422X
dc.identifier.urihttps://hdl.handle.net/10037/21840
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalVirology Journal
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleHPyV6 and HPyV7 in urine from immunocompromised patientsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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