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dc.contributor.authorØstnes Hansen, Kine
dc.contributor.authorHansen, Ida Kristine Østnes
dc.contributor.authorRichard, Céline Sarah Marine
dc.contributor.authorJenssen, Marte
dc.contributor.authorAndersen, Jeanette Hammer
dc.contributor.authorHansen, Espen Holst
dc.date.accessioned2021-07-14T06:12:23Z
dc.date.available2021-07-14T06:12:23Z
dc.date.issued2021-02-21
dc.description.abstractNatural products and their derivatives have served as powerful therapeutics against pathogenic microorganisms and are the mainstay of our currently available treatment options to combat infections. As part of our ongoing search for antimicrobial natural products from marine organisms, one fraction prepared from the Arctic marine bryozoan <i>Securiflustra securifrons</i> was found to be active against the human pathogenic bacterium <i>Streptococcus agalactiae</i> (gr. B). Chemical investigation of the fraction revealed that it contained several variants of the highly modified secondary metabolites known as securamines. The securamines are alkaloids sharing a common isoprene-histamine-tryptamine backbone. In this study, we describe the antimicrobial activities of securamine C, E, and H – J (4, 5, and 1-3) and the attempt to deconvolute the mode of action of 1.en_US
dc.identifier.citationØstnes Hansen KØH, Hansen IKØ, Richard CSM, Jenssen M, Andersen JH, Hansen E. H.. Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons. Natural Product Communications. 2021;16(2):1-8en_US
dc.identifier.cristinIDFRIDAID 1894756
dc.identifier.doi10.1177/1934578X21996180
dc.identifier.issn1934-578X
dc.identifier.issn1555-9475
dc.identifier.urihttps://hdl.handle.net/10037/21871
dc.language.isoengen_US
dc.publisherSAGE Publicationsen_US
dc.relation.ispartofRichard, C.S.M. (2024). Engineering novel bacterial biosensors for the characterization of membrane active natural products. (Doctoral thesis). <a href=https://hdl.handle.net/10037/33610>https://hdl.handle.net/10037/33610</a>
dc.relation.journalNatural Product Communications
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400en_US
dc.titleAntimicrobial Activity of Securamines From the Bryozoan Securiflustra securifronsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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