XTH er en gruppe enzymer som ble oppdaget tidlig på 90 tallet og muligens er involvert i Cuscuta infeksjonen av tomater. En nylig studie gjort ved arktisk og marin biologi UIT viser at Brilliant Blue R250 fungerer som en god inhibitor mot disse enzymene. I dette prosjektet ble det fokusert på å syntetisere strukturelt like molekyler for å potensielt øke vannløseligheten og inhibitoraktiviteten. ...

Oceans all over the world are housing large quantities of plastic pollution and persistent organic pollutants (POPs). Concerns regarding both of them having lipophilic characteristic that allows a successful partitioning of POPs to plastic if in contact in an aqueous medium, led to this study where the relationship between different types of plastic and POPs in the Arctic ocean are looked into. In ...

In this thesis, synthesis of 3 different dibenzylideneacetone (DBA)-analogues and 4 different ethyl 2-oxo-6-phenyl-4-(2-phenylethenyl)-4-cyclohexene-1-carboxylate-analogues that have not been reported before were synthesized, as well as a range of analogues that have been reported before. Both symmetrical and unsymmetrical DBA-analogues were made. The yields of many of these reactions were low, but ...

Antibiotic resistance is threatening the achievements of modern medicine and will evidentially lead to a situation, in which we stand helpless against common bacterial infections. The largest and most widely used group of antibiotics are the β-lactams. One of the major resistance determinants against β-lactam antibiotics is the expression of hydrolytic enzymes, called β-lactamases (BLs). The main ...

It is extensively recognized that an enzyme functions through reducing the energy of activation of its elemental reaction and the catalytic effect of an enzyme is as a result of a change in activation free energy obtained relative to a reference reaction in water of the same mechanism. In this study, chorismate mutase which is an enzyme that catalyzes biochemical reactions for chorismate conversion ...

The last 18 months has shown the impact a single microorganism can have on society with the SARS-CoV-2 virus. This is not the only global threat on our health, with the World Health Organisation and other government agencies warning against the increase in antimicrobial resistance today. Antimicrobial peptides have been seen as a possible solution, as they are known to fight bacteria as a part of ...

The cysteine of HCD (C286) in DYRK1A is involved in disulfide bridge formation with a cysteine (C312) in the DFGSSC sequence. The purpose of this project was to investigate how the state of the disulfide bridge would affect enzyme catalytic and ligand binding properties of the protein kinase. A mutant, DYRK1A C312A, was thus designed to eliminate the disulfide bridge. The mutant was expressed and ...