Mastergradsoppgaver i kjemi: Recent submissions

Now showing items 41-54 of 54

    • Protein-protein binding affinities calculated using the LIE method 

      Andberg, Tor Arne Heim (Master thesis; Mastergradsoppgave, 2011-11-15)
      Absolute binding free energies for the third domain of the turkey ovomucoid inhibitor in complex with Streptomyces griseus proteinase B and porcine pancreatic elastase has been calculated using the linear interaction energy method.

    • Synthesis of Potential Metallo-beta-Lactamase Inhibitors 

      Paulsen, Britt (Master thesis; Mastergradsoppgave, 2011-11-15)

    • Demetalation of metallocorroles 

      Capar, Can (Master thesis; Mastergradsoppgave, 2008-10)
      Although the chemistry of corroles has grown spectacularly in recent years, the field has been marred by the lack of convenient protocols for demetalation of metallocorroles. In this thesis, I have developed a superior procedure for demetalating copper corroles with concentrated H2SO4 and 5-200 equiv FeCl2 or SnCl2. The yields obtained with this reductive procedure are generally substantially ...

    • Purification and characterization of a salt tolerant metallo-beta-lactamase from Aliivibrio salmonicida 

      Kristiansen, Anders (Master thesis; Mastergradsoppgave, 2011-07)
      Beta-lactamases are enzymes that inactivate beta-lactam antibiotics by hydrolyzing the amide bond that exists in the beta-lactam ring, disrupting the ring structure and make the antibiotics nonfunctional against bacteria. Metallo-beta-lactamases (MBLs) are a group of beta-lactamases which needs metal ions bound to its active site in order to function and are an important factor in many bacteria in ...

    • Synthesis of 5-,6-, and 7-membered heterocycles from barbituric acid derivatives 

      Guyader, David (Master thesis; Mastergradsoppgave, 2011-06-10)
      SUMMARY A new procedure has been developed for the synthesis of barbituric acid derivatives. The reactions were performed under solvent free conditions without any catalyst. Employing this synthetic route, a large number of chalconoids and 5-,6-, and 7-membered heterocycles have been successfully synthesized in a very short time. The chalconoids have been synthesized from a barbituric derivative ...

    • The preparation of N-methyliminodiacetic acid protected alkynyl boronates 

      O'Donnell, Michael (Master thesis; Mastergradsoppgave, 2010-06)
      The purpose of this work is to document the attempted syntheses of N-methyliminoacetic acid (MIDA) -protected alkynyl boronates according to procedures and methodologies that have been successfully employed in the syntheses of MIDA-protected alkyl, alkenyl, aryl and heteroaryl boronates. The rationale for the development of this class of MIDA-protected boronates is presented, both in terms of some ...

    • Flexible membrane active antimicrobial tripeptides with stability towards chymotryptic degradation 

      Isaksen, Geir Villy (Master thesis; Mastergradsoppgave, 2010-06-14)
      In recent years antimicrobial peptides have gained a lot of attention due to their potential as a new generation of antibiotics combating the growing problem of antibiotic resistance. It is believed that the amphipathic structure of cationic peptides is a key feature for antimicrobial activity, and that this enables them to interact with the bacterial cell membrane. The conformational space of a ...

    • Nær-orthogonale eksperimenter i organiske syntesereaksjoner 

      Simonsen, Geir (Master thesis; Mastergradsoppgave, 2010-04)
      I avhandlingen prøver jeg å vise hvordan nær-othhogonale eksperimenter kan brukes i screeningforsøk

    • Potassium on potassium-graphite as reagent in the paal-knorr synthesis of 2,5-dimethylthiophene. 

      Okungbowa, Richard Nosa (Master thesis; Mastergradsoppgave, 2009-05-27)
      This thesis describes a new principle for the synthesis of thiophene from diketone. Thiophene is a five-membered heterocyclic aromatic compound containing one sulphur atom. The thiophene structure can be found in certain natural products and is also incorporated in several pharmacologically active compounds. The procedure described in the thesis uses the combination of graphite and metallic ...

    • On the synthesis of pyrylium salts 

      Strømme, Jann H. (Master thesis; Mastergradsoppgave, 2009-05-19)
      Abstract The present work is on the synthesis of a pyrylium salt, 8-hydroxy-2,4-diphenyl-5,6,7,8-tetrahydrochromenylium tetrafluoroborate, a precursor for interesting transition metal ligands. Different routes are presented with the aim of making an affordable precursor for the variety of syntheses possible from these versatile pyrylium salts. New findings include a preparative non optimized ...

    • On the synthesis of a fimbrolide 

      Descomps, Alexandre Pierre (Master thesis; Mastergradsoppgave, 2008-06-30)
      The present work is on the total synthesis of a natural compound found in a mixture of secondary metabolite produced by an alga nearby the cost of Australia. The target molecule, the 4-bromo-3-butyl-5-(dibromomethylene)furan-2(5H)-one, has not previously been proposed. The synthetic route described in this thesis uses cheap and readily available starting materials and the target is reached after six ...

    • Bonding in a triamidoamine-supported chromium(III) carbonyl 

      Nkeng, Agbor Moses (Master thesis; Mastergradsoppgave, 2008-05-15)
      Cr(III) metal ion in low spin triamidoamine-supported chromium(III) carbonyl complex {[(RN)3N]CrCO, 1} has a unique feature of S=1/2 being unusual for a Cr(III) metal ion, which is high spin with S=3/2 in most complexes and this gives us the basis for this theoretical study. The primary preoccupation has been to determine the electronic ground state and other low-energy state with much emphasis ...

    • Syntese av klorerte fettsyrer til bruk som standarder i miljøanalyser 

      Lauknes, Kristian (Master thesis; Mastergradsoppgave, 2007-06-20)
      Mettede C-16 og C-18 klorerte fettsyrer ble syntetisert til bruk som miljøstandarder. De mettede klorerte fettsyrene hører sammen med en ny type miljøgift nemlig klorerte fettsyrer (ClFA). Dette er en type miljøgift som man per dags dato ikke har så mye kunnskap om, men som er blitt påvist i en rekke forskjellige fiskearter. Hvilken effekt de vil ha på mennesker eller andre pattedyr på toppen av ...

    • High valent transition metal corrole and corrolazine complexes. The question of noninnocent ligands 

      Tangen, Espen (Master thesis; Mastergradsoppgave, 2003-06-06)
      To contribute to the fundamental picture of the electronic structure of high valent first row transition metal complexes, I have carried out a density functional study of two different macrocyclic ligand systems, corroles and corrolazines, with two different axial ligands, Ph and Cl and a number of different central ions, P(V), Cu(III), Mn(IV) and Fe(IV). DFT calculations on Fe(IV) and Mn(IV) corrole ...