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dc.contributor.authorNedberg, Nora Hersoug
dc.contributor.authorTurowski, Gitta Erika
dc.contributor.authorGuz, Katarzyna
dc.contributor.authorPrzytuła, Ewa
dc.contributor.authorUhrynowska, Małgorzata
dc.contributor.authorRoald, Borghild
dc.contributor.authorHusebekk, Anne
dc.contributor.authorSitras, Vasilis
dc.contributor.authorNystad, Mona
dc.contributor.authorDębska, Marzena
dc.contributor.authorBrojer, Ewa
dc.contributor.authorTiller, Heidi
dc.date.accessioned2021-09-30T09:00:39Z
dc.date.available2021-09-30T09:00:39Z
dc.date.issued2021-07-23
dc.description.abstract<i>Introduction</i> - Maternal alloimmunization against human platelet antigen (HPA)-1a has been implied to mediate both reduced birth weight and chronic placental inflammation. Fetal growth restriction is associated with different types of chronic inflammation in the placenta, mainly chronic histiocytic intervillositis and chronic villitis. The aim of this prospective study was to do a systematic examination of placentas from HPA-1a alloimmunized pregnancies, with focus on the histopathological and immunohistochemical diagnosis of variants of chronic inflammation.<br><br> <i>Material and methods</i> - In a Polish-Norwegian study, 48 placentas were examined. The histopathology of placentas from 27 HPA-1a immunized women was compared with 21 placentas from non-immunized HPA-1a negative women (controls). In the group of alloimmunized women, ten received antenatal intravenous immunoglobulin G (IVIg). Tissue sections from formalin fixed paraffin embedded placental tissue were stained with hematoxylin and eosin and microscopically examined with focus on various types of chronic placental inflammations.<br><br> <i>Results</i> - Chronic histiocytic intervillositis was observed in 40.7% of placentas from HPA-1a alloimmunized pregnancies, compared to none in the control group (p = 0.001). Chronic villitis of unknown etiology was more frequently found in the alloimmunized group, however this difference was not statistically significant. Maternal administration of IVIg did not seem to protect against chronic inflammatory lesions.<br><br> <i>Discussion</i> - Placentas with detectable maternal anti-HPA-1a antibodies are associated with highly increased risk of low-grade chronic histiocytic intervillositis.en_US
dc.identifier.citationNedberg, Turowski, Guz, Przytuła, Uhrynowska, Roald, Husebekk, Sitras, Nystad, Dębska, Brojer, Tiller. Platelet alloimmunization is associated with low grade chronic histiocytic intervillositis - A new link to a rare placental lesion?. Placenta. 2021;112:89-96en_US
dc.identifier.cristinIDFRIDAID 1924405
dc.identifier.doi10.1016/j.placenta.2021.07.291
dc.identifier.issn0143-4004
dc.identifier.issn1532-3102
dc.identifier.urihttps://hdl.handle.net/10037/22688
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalPlacenta
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titlePlatelet alloimmunization is associated with low grade chronic histiocytic intervillositis - A new link to a rare placental lesion?en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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