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dc.contributor.authorStorm, Benjamin
dc.contributor.authorHalvorsen, Per Steinar
dc.contributor.authorSkulstad, Helge
dc.contributor.authorDybwik, Knut Gustav
dc.contributor.authorSchjalm, Camilla
dc.contributor.authorChristiansen, Dorte
dc.contributor.authorWisløff-Aase, Kristin
dc.contributor.authorFosse, Erik
dc.contributor.authorBraaten, Tonje Bjørndal
dc.contributor.authorNielsen, Erik Waage
dc.contributor.authorMollnes, Tom Eirik
dc.date.accessioned2021-11-01T21:16:38Z
dc.date.available2021-11-01T21:16:38Z
dc.date.issued2021-02-17
dc.description.abstract<p><i>Background:</i> Transpulmonary passage of air emboli can lead to fatal brain- and myocardial infarctions. We studied whether pigs with open chest and pericardium had a greater transpulmonary passage of venous air emboli than pigs with closed thorax. <p><i>Methods:</i> We allocated pigs with verified closed foramen ovale to venous air infusion with either open chest with sternotomy and opening of the pleura and pericardium (n = 8) or closed thorax (n = 16). All pigs received a five-hour intravenous infusion of ambient air, starting at 4-6 mL/kg/h and increased by 2 mL/kg/h each hour. We assessed transpulmonary air passage by transesophageal M-mode echocardiography and present the results as median with inter-quartile range (IQR). <p><i>Results:</i> Transpulmonary air passage occurred in all pigs with open chest and pericardium and in nine pigs with closed thorax (56%). Compared to pigs with closed thorax, pigs with open chest and pericardium had a shorter to air passage (10 minutes (5-16) vs. 120 minutes (44-212), P < .0001), a smaller volume of infused air at the time of transpulmonary passage (12 mL (10-23) vs.170 mL (107-494), P < .0001), shorter time to death (122 minutes (48-185) vs 263 minutes (248-300, P = .0005) and a smaller volume of infused air at the time of death (264 mL (53-466) vs 727 mL (564-968), P = .001). In pigs with open chest and, infused air and time to death correlated strongly (r = 0.95, P = .001). <p><i>Conclusion:</i> Open chest and pericardium facilitated the transpulmonary passage of intravenously infused air in pigs.en_US
dc.identifier.citationStorm, Halvorsen, Skulstad, Dybwik, Schjalm, Christiansen, Wisløff-Aase, Fosse, Braaten, Nielsen, Mollnes. Open chest and pericardium facilitate transpulmonary passage of venous air emboli. Acta Anaesthesiologica Scandinavica. 2021;65(5):648-655en_US
dc.identifier.cristinIDFRIDAID 1916746
dc.identifier.doi10.1111/aas.13796
dc.identifier.issn0001-5172
dc.identifier.issn1399-6576
dc.identifier.urihttps://hdl.handle.net/10037/22910
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalActa Anaesthesiologica Scandinavica
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Vascular and thoracic surgery: 782en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kar- og thoraxkirurgi: 782en_US
dc.titleOpen chest and pericardium facilitate transpulmonary passage of venous air embolien_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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