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dc.contributor.authorMorseth, Bente
dc.contributor.authorGeelhoed, Bastiaan
dc.contributor.authorLinneberg, Allan
dc.contributor.authorJohansson, Lars
dc.contributor.authorKuulasmaa, Kari
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorIacoviello, Licia
dc.contributor.authorConstanzo, Simona
dc.contributor.authorSöderberg, Stefan
dc.contributor.authorNiiranen, Teemu
dc.contributor.authorVishram, Julie K.K.
dc.contributor.authorNjølstad, Inger
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorZeller, Tanja
dc.contributor.authorBlankenberg, Stefan
dc.contributor.authorOjeda, Francisco
dc.contributor.authorSchnabel, Renate B.
dc.date.accessioned2021-11-01T22:19:11Z
dc.date.available2021-11-01T22:19:11Z
dc.date.issued2021-08-02
dc.description.abstract<p><i>Background:</i> The main aim was to examine age-specific risk factor associations with incident atrial fibrillation (AF) and their attributable fraction in a large European cohort. Additionally, we aimed to examine risk of stroke and mortality in relation to new-onset AF across age. <p><i>Methods:</i> We used individual-level data (n=66 951, 49.1% men, age range 40–98 years at baseline) from five European cohorts of the MOnica Risk, Genetics, Archiving and Monograph Consortium. The participants were followed for incident AF for up to 10 years and the association with modifiable risk factors from the baseline examinations (body mass index (BMI), hypertension, diabetes, daily smoking, alcohol consumption and history of stroke and myocardial infarction (MI)) was examined. Additionally, the participants were followed up for incident stroke and all-cause mortality after new-onset AF. <p><i>Results:</i> AF incidence increased from 0.9 per 1000 person-years at baseline age 40–49 years, to 17.7 at baseline age ≥70 years. Multivariable-adjusted Cox models showed that higher BMI, hypertension, high alcohol consumption and a history of stroke or MI were associated with increased risk of AF across age groups (p<0.05). Between 30% and 40% of the AF risk could be attributed to BMI, hypertension and a history of stroke or MI. New-onset AF was associated with a twofold increase in risk of stroke and death at ages≥70 years (p≤0.001). <p><i>Conclusion:</i> In this large European cohort aged 40 years and above, risk of AF was largely attributed to BMI, high alcohol consumption and a history MI or stroke from middle age. Thus, preventive measures for AF should target risk factors such as obesity and hypertension from early age and continue throughout life.en_US
dc.identifier.citationMorseth B, Geelhoed B, Linneberg A, Johansson L, Kuulasmaa K, Salomaa V, Iacoviello L, Constanzo S, Söderberg S, Niiranen T, Vishram JK, Njølstad i, Wilsgaard T, Mathiesen EB, Løchen M, Zeller T, Blankenberg S, Ojeda F, Schnabel RB. Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium. Open heart. 2021;8(2)en_US
dc.identifier.cristinIDFRIDAID 1927868
dc.identifier.doi10.1136/openhrt-2021-001624
dc.identifier.issn2053-3624
dc.identifier.urihttps://hdl.handle.net/10037/22911
dc.language.isoengen_US
dc.publisherBMJen_US
dc.relation.journalOpen heart
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FR7/201413/EU/European Network for Genetic and Genomic Epidemiology/ENGAGE/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FR7/242244/EU/Consortium on Health and Ageing: Network of Cohorts in Europe and the United States/CHANCES/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FR7/278913/EU/Biomarker for Cardiovascular Risk Assessment in Europe/BiomarCaRE/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/825903/EU/An EU-Canada joint infrastructure for next-generation multi-Study Heart research/euCanSHare/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/847770/EU/DIGITAL, RISK-BASED SCREENING FOR ATRIAL FIBRILLATION IN THE EUROPEAN COMMUNITY/AFFECT-EU/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/648131/EU/Novel multimodal approach to atrial fibrillation risk assessment and identification of targets for prevention by interdisciplinary exploitation of omics, advanced electrocardiography, and imaging/MMAF/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.titleAge-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortiumen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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