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dc.contributor.authorJohansen Dagenborg, Vegard
dc.contributor.authorMarshall, Serena Elizabeth
dc.contributor.authorGrzyb, Krzyzstof
dc.contributor.authorFretland, Åsmund Avdem
dc.contributor.authorLund-Iversen, Marius
dc.contributor.authorMælandsmo, Gunhild Mari
dc.contributor.authorHansen Ree, Anne
dc.contributor.authorEdwin, Bjørn
dc.contributor.authorYaqub, Sheraz
dc.contributor.authorFlatmark, Kjersti
dc.date.accessioned2021-11-19T08:37:12Z
dc.date.available2021-11-19T08:37:12Z
dc.date.issued2021-06-09
dc.description.abstractBackground: The subtype, density and location of tumor infiltrating T-cells are being explored as prognostic and predictive biomarkers in primary colorectal cancer (pCRC) and colorectal liver metastases (CLM). Very limited data exist comparing findings in pCRC and matched CLM.<p> <p>Patients and methods: Fifty-eight patients with available pCRC and matched CLM (57/58 microsatellite stable) were included in this OSLO-COMET substudy. In immunohistochemically stained sections, total (Ttot), helper (TH), cytotoxic (CTL), and regulatory (Treg) T-cells were manually counted in hotspots from the invasive margin (IM), intratumor (IT), and tumor adjacent regions to determine T-cell densities.<p> <p>Results: A striking accumulation of T-cells was found in IM of both pCRC and CLM with much lower densities in the IT region, exemplified by Ttot of 2838 versus 340 cells/mm2, respectively, in CLM. The correlation at the individual level between T-cell densities in pCRC and corresponding CLM was poor for all regions and T-cell subtypes; for instance, the correlation coefficient (R2) for IM Ttot was 0.07. The IT TH : CTL and Treg : TH ratios were 2.94 and 0.44, respectively, in pCRC, and 1.84 and 0.24, respectively, in CLM.<p> <p>Conclusion: The observed accumulation of T-cells in the IM regions of pCRC and CLM with low penetration to the IT regions, combined with high TH : CTL and Treg : TH ratios, point to the presence of an immune suppressive microenvironment. T-cell densities of CLM differed markedly from the matched pCRC, indicating that to evaluate T-cell biomarkers in metastasis, the commonly available pCRC cannot serve as a surrogate for the metastatic tumor.en_US
dc.identifier.citationJohansen Dagenborg, Marshall, Grzyb, Fretland, Lund-Iversen, Mælandsmo, Hansen Ree, Edwin, Yaqub, Flatmark. Low Concordance Between T-Cell Densities in Matched Primary Tumors and Liver Metastases in Microsatellite Stable Colorectal Cancer. Frontiers in Oncology. 2021;11:1-9en_US
dc.identifier.cristinIDFRIDAID 1947905
dc.identifier.doi10.3389/fonc.2021.671629
dc.identifier.issn2234-943X
dc.identifier.urihttps://hdl.handle.net/10037/23077
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Oncology
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEHANDLING/218325/Norway/MetAction: Actionable Targets in Cancer Metastasis - from Bed to Bench to Byte to Bedside//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleLow Concordance Between T-Cell Densities in Matched Primary Tumors and Liver Metastases in Microsatellite Stable Colorectal Canceren_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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