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dc.contributor.authorMartínez de Toda, Irene
dc.contributor.authorRattan, Suresh IS
dc.contributor.authorDe la Fuente, Mónica
dc.contributor.authorArranz, Lorena
dc.date.accessioned2021-11-19T08:48:35Z
dc.date.available2021-11-19T08:48:35Z
dc.date.issued2021-08-31
dc.description.abstractOxidized, damaged and misfolded proteins accumulate during aging and contribute to impaired cell function and tissue homeodynamics. Damaged proteins are degraded by cellular clearance mechanisms like the 20S proteasome. Aging relates to low 20S proteasome function, whereas long-lived species show high levels. However, contradictory results exist depending on the tissue or cell type and it is unknown how the 20S proteasome functions in exceptionally old mice. The aim of this study was to investigate two proteasome activities (caspase-like and chymotrypsin-like) in several tissues (lung, heart, axillary lymph nodes, liver, kidney) and cells (peritoneal leukocytes) from adult (28 ± 4 weeks, n = 12), old (76 ± 4 weeks, n = 9) and exceptionally old (128 ± 4 weeks, n = 9) BALB/c female mice. The results show different age-related changes depending on the tissue and the activity considered, so there is no universal decline in proteasome function with age in female mice. Interestingly, exceptionally old mice displayed better maintained proteasome activities, suggesting that preserved 20S proteasome is associated with successful agingen_US
dc.identifier.citationMartínez de Toda, Rattan, De la Fuente, Arranz L. Female Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activities. Antioxidants. 2021;10(9):1397en_US
dc.identifier.cristinIDFRIDAID 1948681
dc.identifier.doi10.3390/antiox10091397
dc.identifier.issn2076-3921
dc.identifier.urihttps://hdl.handle.net/10037/23080
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalAntioxidants
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEHANDLING/247596/Norway/Neuroglial Regulation of the Haematopoietic Stem Cell Niche in Acute Myeloid Leukaemia Transformation//en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/250901/Norway/Stem Cell Metabolic Dysfunction in Myeloid Leukaemia and its Therapeutic Targeting//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical molecular biology: 711en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711en_US
dc.titleFemale Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activitiesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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