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dc.contributor.authorKleive, Dyre
dc.contributor.authorAas, Eline
dc.contributor.authorBringeland, Erling Audun
dc.contributor.authorNesbakken, Arild
dc.contributor.authorNymo, Linn Såve
dc.contributor.authorSchultz, Johannes Kurt
dc.contributor.authorSøreide, Kjetil
dc.contributor.authorYaqub, Sheraz
dc.date.accessioned2021-11-24T08:38:53Z
dc.date.available2021-11-24T08:38:53Z
dc.date.issued2021-03-23
dc.description.abstractThe timing of surgical resection of synchronous liver metastases from colorectal cancer has been debated for decades. Several strategies have been proposed, but high-level evidence remains scarce. Simultaneous resection of the primary tumour and liver metastases has been described in numerous retrospective audits and meta-analyses. The potential benefits of simultaneous resections are the eradication of the tumour burden in one procedure, overall shorter procedure time, reduced hospital stay with the likely benefits on quality of life and an expected reduction in the use of health care services compared to staged procedures. However, concerns about accumulating complications and oncological outcomes remain and the optimal selection criteria for whom simultaneous resections are beneficial remains undetermined. Based on the current level of evidence, simultaneous resection should be restricted to patients with a limited liver tumour burden. More high-level evidence studies are needed to evaluate the quality of life, complication burden, oncological outcomes, as well as overall health care implications for simultaneous resections.en_US
dc.identifier.citationKleive D, Aas E, Angelsen J, Bringeland Ea, Nesbakken A, Nymo LS, Schultz JK, Søreide K, Yaqub S. Simultaneous Resection of Primary Colorectal Cancer and Synchronous Liver Metastases: Contemporary Practice, Evidence and Knowledge Gaps. Oncology and Therapy. 2021;9(11)en_US
dc.identifier.cristinIDFRIDAID 1956365
dc.identifier.doi10.1007/s40487-021-00148-2
dc.identifier.issn2366-1089
dc.identifier.urihttps://hdl.handle.net/10037/23147
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalOncology and Therapy
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleSimultaneous Resection of Primary Colorectal Cancer and Synchronous Liver Metastases: Contemporary Practice, Evidence and Knowledge Gapsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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