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dc.contributor.authorPaulsen, Benedikte
dc.contributor.authorGran, Olga Vikhammer
dc.contributor.authorSeverinsen, Marianne T.
dc.contributor.authorHammerstrøm, Jens
dc.contributor.authorKristensen, Søren Risom
dc.contributor.authorCannegieter, Suzanne C.
dc.contributor.authorSkille, Hanne
dc.contributor.authorTjønneland, Anne
dc.contributor.authorRosendaal, Frits
dc.contributor.authorOvervad, Kim
dc.contributor.authorNæss, Inger Anne
dc.contributor.authorHansen, John-Bjarne
dc.contributor.authorBrækkan, Sigrid K.
dc.date.accessioned2021-11-25T07:23:44Z
dc.date.available2021-11-25T07:23:44Z
dc.date.issued2021-09-21
dc.description.abstractSmoking is a well-established risk factor for cancer, and cancer patients have a high risk of venous thromboembolism (VTE). Conflicting results have been reported on the association between smoking and risk of VTE, and the effect of smoking on VTE-risk in subjects with cancer is scarcely studied. We aimed to investigate the association between smoking and VTE in subjects with and without cancer in a large population-based cohort. The Scandinavian Thrombosis and Cancer (STAC) cohort included 144,952 participants followed from 1993–1997 to 2008–2012. Information on smoking habits was derived from self-administered questionnaires. Active cancer was defined as the first two years following the date of cancer diagnosis. Former smokers (n = 35,890) and those with missing information on smoking status (n = 3680) at baseline were excluded. During a mean follow up of 11 years, 10,181 participants were diagnosed with cancer, and 1611 developed incident VTE, of which 214 were cancer-related. Smoking was associated with a 50% increased risk of VTE (HR 1.49, 95% CI 1.12–1.98) in cancer patients, whereas no association was found in cancer-free subjects (HR 1.07, 95% CI 0.96–1.20). In cancer patients, the risk of VTE among smokers remained unchanged after adjustment for cancer site and metastasis. Stratified analyses showed that smoking was a risk factor for VTE among those with smoking-related and advanced cancers. In conclusion, smoking was associated with increased VTE risk in subjects with active cancer, but not in those without cancer. Our findings imply a biological interaction between cancer and smoking on the risk of VTE.en_US
dc.identifier.citationPaulsen, Gran, Severinsen, Hammerstrøm, Kristensen, Cannegieter, Skille, Tjønneland, Rosendaal, Overvad, Næss, Hansen, Brækkan. Association of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohort. Scientific Reports. 2021;11(1):1-9en_US
dc.identifier.cristinIDFRIDAID 1942877
dc.identifier.doi10.1038/s41598-021-98062-0
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/23159
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleAssociation of smoking and cancer with the risk of venous thromboembolism: the Scandinavian Thrombosis and Cancer cohorten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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