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dc.contributor.authorKarlsen, Eskil André
dc.contributor.authorStensen, Wenche
dc.contributor.authorJuskewitz, Eric
dc.contributor.authorSvenson, Johan
dc.contributor.authorBerglin, Mattias
dc.contributor.authorSvendsen, John Sigurd Mjøen
dc.date.accessioned2021-12-16T13:03:01Z
dc.date.available2021-12-16T13:03:01Z
dc.date.issued2021-12-10
dc.description.abstractMedical devices with an effective anti-colonization surface are important tools for combatting healthcare-associated infections. Here, we investigated the anti-colonization efficacy of antimicrobial peptides covalently attached to a gold model surface. The gold surface was modified by a self-assembled polyethylene glycol monolayer with an acetylene terminus. The peptides were covalently connected to the surface through a copper-catalyzed [3 + 2] azide-acetylene coupling (CuAAC). The anti-colonization efficacy of the surfaces varied as a function of the antimicrobial activity of the peptides, and very effective surfaces could be prepared with a 6 log unit reduction in bacterial colonization.en_US
dc.identifier.citationKarlsen, Stensen, Juskewitz, Svenson, Berglin, Svendsen. Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on S. epidermidis. Antibiotics. 2021en_US
dc.identifier.cristinIDFRIDAID 1967175
dc.identifier.doi10.3390/antibiotics10121516
dc.identifier.issn2079-6382
dc.identifier.urihttps://hdl.handle.net/10037/23420
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.ispartofJuskewitz, E. (2022). Antimicrobial activity and mode of action - Examples from natural products, peptides, and peptidomimetics. (Doctoral thesis). <a href=https://hdl.handle.net/10037/25912>https://hdl.handle.net/10037/25912</a>.
dc.relation.journalAntibiotics
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/NAERINGSPH/283272/Norway/Preparation of novel antimicrobial peptides for surface immobiolisation//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440en_US
dc.titleAnti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on S. epidermidisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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