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dc.contributor.authorFasth Markussen, Fredrik Andreas
dc.contributor.authorMelum, Vebjørn Jacobsen
dc.contributor.authorHazlerigg, David
dc.date.accessioned2021-12-21T12:26:08Z
dc.date.available2021-12-21T12:26:08Z
dc.date.issued2021-01-07
dc.description.abstractBackground - Hibernation is a physiological and behavioural adaptation that permits survival during periods of reduced food availability and extreme environmental temperatures. This is achieved through cycles of metabolic depression and reduced body temperature (torpor) and rewarming (arousal). Rewarming from torpor is achieved through the activation of brown adipose tissue (BAT) associated with a rapid increase in ventilation frequency. Here, we studied the rate of rewarming in the European hamster (Cricetus cricetus) by measuring both BAT temperature, core body temperature and ventilation frequency.<p> <p>Results - Temperature was monitored in parallel in the BAT (IPTT tags) and peritoneal cavity (iButtons) during hibernation torpor-arousal cycling. We found that increases in brown fat temperature preceded core body temperature rises by approximately 48 min, with a maximum re-warming rate of 20.9℃*h<sup>-1</sup>. Re-warming was accompanied by a significant increase in ventilation frequency. The rate of rewarming was slowed by the presence of a spontaneous thoracic mass in one of our animals. Core body temperature re-warming was reduced by 6.2℃*h<sup>-1</sup> and BAT rewarming by 12℃*h<sup>-1</sup>. Ventilation frequency was increased by 77% during re-warming in the affected animal compared to a healthy animal. Inspection of the position and size of the mass indicated it was obstructing the lungs and heart.<p> <p>Conclusions - We have used a minimally invasive method to monitor BAT temperature during arousal from hibernation illustrating BAT re-warming significantly precedes core body temperature re-warming, informing future study design on arousal from hibernation. We also showed compromised re-warming from hibernation in an animal with a mass obstructing the lungs and heart, likely leading to inefficient ventilation and circulation.en_US
dc.identifier.citationFasth Markussen, Melum, Hazlerigg. A refined method to monitor arousal from hibernation in the European hamster. BMC Veterinary Research. 2021en_US
dc.identifier.cristinIDFRIDAID 1962969
dc.identifier.doi10.1186/s12917-020-02723-7
dc.identifier.issn1746-6148
dc.identifier.urihttps://hdl.handle.net/10037/23461
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Veterinary Research
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/?/?/Norway?/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480en_US
dc.titleA refined method to monitor arousal from hibernation in the European hamsteren_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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