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dc.contributor.authorAchten, Niek B.
dc.contributor.authorPlötz, Frans B.
dc.contributor.authorKlingenberg, Claus
dc.contributor.authorStocker, Martin
dc.contributor.authorBokelaar, Robin
dc.contributor.authorBijlsma, Merijn
dc.contributor.authorGiannoni, Eric
dc.contributor.authorvan Rossum, Annemarie M.C.
dc.contributor.authorBenitz, William E.
dc.date.accessioned2021-12-22T11:30:23Z
dc.date.available2021-12-22T11:30:23Z
dc.date.issued2021-02-03
dc.description.abstractObjectives - To provide a comprehensive assessment of case stratification by the Neonatal Early-Onset Sepsis (EOS) Calculator, a novel tool for reducing unnecessary antibiotic treatment.<p> <p>Study design - A systematic review with individual patient data meta-analysis was conducted, extending PROSPERO record CRD42018116188. Cochrane, PubMed/MEDLINE, EMBASE, Web of Science, Google Scholar, and major conference proceedings were searched from 2011 through May 1, 2020. Original data studies including culture-proven EOS case(s) with EOS Calculator application, independent from EOS Calculator development, and including representative birth cohorts were included. Relevant (individual patient) data were extracted from full-text and data queries. The main outcomes were the proportions of EOS cases assigned to risk categories by the EOS Calculator at initial assessment and within 12 hours. Evidence quality was assessed using Newcastle-Ottawa scale, Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies, and GRADE tools.<p> <p>Results - Among 543 unique search results, 18 were included, totaling more than 459 000 newborns. Among 234 EOS cases, EOS Calculator application resulted in initial assignments to (strong consideration of) empiric antibiotic administration for 95 (40.6%; 95% CI, 34.2%-47.2%), more frequent vital signs for 36 (15.4%; 95% CI, 11.0%-20.7%), and routine care for 103 (44.0%; 95% CI, 37.6%-50.6%). By 12 hours of age, these proportions changed to 143 (61.1%; 95% CI, 54.5%-67.4%), 26 (11.1%; 95% CI, 7.4%-15.9%), and 65 (27.8%; 95% CI, 22.1%-34.0%) of 234 EOS cases, respectively.<p> <p>Conclusions - EOS Calculator application assigns frequent vital signs or routine care to a substantial proportion of EOS cases. Clinical vigilance remains essential for all newborns.en_US
dc.identifier.citationAchten, Plötz, Klingenberg, Stocker, Bokelaar, Bijlsma, Giannoni, van Rossum, Benitz. Stratification of Culture-Proven Early-Onset Sepsis Cases by the Neonatal Early-Onset Sepsis Calculator: An Individual Patient Data Meta-Analysis. Journal of Pediatrics. 2021;234:77-84en_US
dc.identifier.cristinIDFRIDAID 1918569
dc.identifier.doi10.1016/j.jpeds.2021.01.065
dc.identifier.issn0022-3476
dc.identifier.urihttps://hdl.handle.net/10037/23477
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of Pediatrics
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleStratification of Culture-Proven Early-Onset Sepsis Cases by the Neonatal Early-Onset Sepsis Calculator: An Individual Patient Data Meta-Analysisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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