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dc.contributor.authorMoreiras-Figueruelo, Alejandro
dc.contributor.authorNuzzo, Genoveffa
dc.contributor.authorGalasso, Christian
dc.contributor.authorSansone, Clementina
dc.contributor.authorCrocetta, Fabio
dc.contributor.authorMazzella, Valerio
dc.contributor.authorGallo, Carmela
dc.contributor.authorBarra, Giusi
dc.contributor.authorSardo, Angela
dc.contributor.authorIuliano, Antonella
dc.contributor.authorManzo, Emiliano
dc.contributor.authorD’ippolito, Giuliana
dc.contributor.authorAlbrigtsen, Marte
dc.contributor.authorAndersen, Jeanette H.
dc.contributor.authorIanora, Adrianna
dc.contributor.authorFontana, Angelo
dc.date.accessioned2021-12-28T11:08:46Z
dc.date.available2021-12-28T11:08:46Z
dc.date.issued2021-11-16
dc.description.abstractThe marine environment is potentially a prolific source of small molecules with significant biological activities. In recent years, the development of new chromatographic phases and the progress in cell and molecular techniques have facilitated the search for marine natural products (MNPs) as novel pharmacophores and enhanced the success rate in the selection of new potential drug candidates. However, most of this exploration has so far been driven by anticancer research and has been limited to a reduced number of taxonomic groups. In this article, we report a test study on the screening potential of an in-house library of natural small molecules composed of 285 samples derived from 57 marine organisms that were chosen from among the major eukaryotic phyla so far represented in studies on bioactive MNPs. Both the extracts and SPE fractions of these organisms were simultaneously submitted to three different bioassays—two phenotypic and one enzymatic—for cytotoxic, antidiabetic, and antibacterial activity. On the whole, the screening of the MNP library selected 11 potential hits, but the distribution of the biological results showed that SPE fractionation increased the positive score regardless of the taxonomic group. In many cases, activity could be detected only in the enriched fractions after the elimination of the bulky effect due to salts. On a statistical basis, sponges and molluscs were confirmed to be the most significant source of cytotoxic and antimicrobial products, but other phyla were found to be effective with the other therapeutic targetsen_US
dc.identifier.citationMoreiras-Figueruelo, Nuzzo, Galasso, Sansone, Crocetta, Mazzella, Gallo, Barra, Sardo, Iuliano, Manzo, D’ippolito, Albrigtsen, Andersen, Ianora, Fontana. Probing the therapeutic potential of marine phyla by spe extraction. Marine Drugs. 2021;19(11)en_US
dc.identifier.cristinIDFRIDAID 1963578
dc.identifier.doi10.3390/md19110640
dc.identifier.issn1660-3397
dc.identifier.urihttps://hdl.handle.net/10037/23519
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalMarine Drugs
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480en_US
dc.titleProbing the therapeutic potential of marine phyla by spe extractionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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