dc.contributor.author | Evensen, Line Holtet | |
dc.contributor.author | Folsom, Aaron R. | |
dc.contributor.author | Pankow, James S. | |
dc.contributor.author | Hansen, John-Bjarne | |
dc.contributor.author | Allison, Matthew | |
dc.contributor.author | Cushman, Mary | |
dc.contributor.author | Lutsey, Pamela L. | |
dc.date.accessioned | 2022-01-10T14:21:36Z | |
dc.date.available | 2022-01-10T14:21:36Z | |
dc.date.issued | 2021-03-27 | |
dc.description.abstract | Background - Several hemostatic factors and inflammatory markers are associated with the risk of incident venous thromboembolism (VTE), however, most existing data are from case-control studies in Caucasian populations.<p>
<p>Objectives - We aimed to prospectively confirm previous findings and explore less studied biomarkers in relation to VTE risk in a multi-racial/multi-ethnic cohort.<p>
<p>Methods - Circulating levels of factor VIII, fibrinogen, D-dimer, plasmin-antiplasmin complex (PAP), C-reactive protein (CRP), and interleukin-6 (IL-6) were measured at baseline (2000–2002) in 6706 participants of the Multi-Ethnic Study of Atherosclerosis. Incident VTE was identified using hospitalization discharge codes from baseline to December 31, 2015. Hazard ratios (HRs) of VTE were estimated in Cox regression models.<p>
<p>Results - There were 227 events during a median of 14 years of follow-up. Compared with participants in the lowest quartile, the HRs for those above the 95th percentile and p for trend across categories were 3.50 (95% confidence interval [CI] 1.98–6.19; p < .001) for D-dimer, 1.49 (95% CI 0.84–2.63; p = .02) for factor VIII, 1.32 (95% CI 0.76–2.28; p = .99) for fibrinogen, 1.92 (95% CI 1.08–3.42; p = .15) for PAP, 1.68 (95% CI 0.81–3.48; p = .08) for CRP, and 2.55 (95% CI 1.15–5.66; p = .07) for IL-6, after adjustment for demographics and body mass index. For CRP and IL-6, follow-up was restricted to 10 years because of violations of the proportional hazards assumption. No significant interactions by age/ethnicity were observed.<p>
<p>Conclusions - We demonstrated a fairly novel association between PAP and risk of incident VTE, and contributed further prospective confirmation regarding the associations of D-dimer, factor VIII, and IL-6 with VTE. | en_US |
dc.identifier.citation | Evensen L, Folsom, Pankow, Hansen JB, Allison, Cushman, Lutsey. Hemostatic factors, inflammatory markers, and risk of incident venous thromboembolism: The Multi-Ethnic Study of Atherosclerosis. Journal of Thrombosis and Haemostasis. 2021:1-11 | en_US |
dc.identifier.cristinID | FRIDAID 1918008 | |
dc.identifier.doi | 10.1111/jth.15315 | |
dc.identifier.issn | 1538-7933 | |
dc.identifier.issn | 1538-7836 | |
dc.identifier.uri | https://hdl.handle.net/10037/23655 | |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.relation.journal | Journal of Thrombosis and Haemostasis | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2021 The Author(s) | en_US |
dc.title | Hemostatic factors, inflammatory markers, and risk of incident venous thromboembolism: The Multi-Ethnic Study of Atherosclerosis | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |