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dc.contributor.authorVarsi, Kristin
dc.contributor.authorHuber, Sandra
dc.contributor.authorAverina, Maria
dc.contributor.authorBrox, Jan
dc.contributor.authorMonsen, Anne-Lise Bjørke
dc.contributor.authorTorsvik, Ingrid Kristin
dc.date.accessioned2022-02-14T10:54:04Z
dc.date.available2022-02-14T10:54:04Z
dc.date.issued2021-11-17
dc.description.abstractIndustrial produced perfluoroalkyl substances (PFAS) are environmentally persistent and found in humans around the globe. PFAS is transferred from mother to child during pregnancy and lactation and PFAS concentrations are high in infants. PFAS exposure in early life has been linked to a range of negative health effects. In the present study we have investigated PFAS concentrations in mothers (pregnancy week 18, 28 and 36 and six weeks, four and six months postpartum, n = 114) and in infants at six months age (n = 94), and studied the effects of PFAS status on infant gross motor development by Alberta Infant Motor Scale (AIMS) at age six months. PFAS concentrations declined in the mothers during pregnancy and postpartum period, and the highest concentrations were seen in infants aged six months. Parity was a strong negative predictor and fish intake a strong positive predictor of maternal PFAS status, while maternal concentrations of PFAS in pregnancy week 18 and months of exclusive breastfeeding determined the PFAS concentrations in infants at six months. Infants who scored below the median on gross motor development had higher PFAS concentrations than infants with a better gross motor development. Ninety percent of the women reported having fish for dinner at least once a week, with fatty fish as the most popular choice (72%). A higher maternal fish intake in pregnancy week 18 was associated with a poorer gross motor development in the infants at six months. Infant gross motor development is a marker of later cognitive outcome and our findings indicate that higher PFAS concentrations in young infants and maternal fatty fish intake may impair neurodevelopment.en_US
dc.identifier.citationVarsi K, Torsvik IK, Huber SH, Averina M, Brox J, Monsen ALB. Impaired gross motor development in infants with higher PFAS concentrations. Environmental Research. 2021;204en_US
dc.identifier.cristinIDFRIDAID 1966458
dc.identifier.doi10.1016/j.envres.2021.112392
dc.identifier.issn0013-9351
dc.identifier.issn1096-0953
dc.identifier.urihttps://hdl.handle.net/10037/24040
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEnvironmental Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleImpaired gross motor development in infants with higher PFAS concentrationsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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