Vis enkel innførsel

dc.contributor.authorAbudu, Yakubu Princely
dc.contributor.authorShrestha, Birendra Kumar
dc.contributor.authorZhang, Wenxin
dc.contributor.authorPalara, Anthimi
dc.contributor.authorBrenne, Hanne Britt
dc.contributor.authorLarsen, Kenneth Bowitz
dc.contributor.authorWolfson, Deanna
dc.contributor.authorDumitriu, Gianina
dc.contributor.authorØie, Cristina Ionica
dc.contributor.authorAhluwalia, Balpreet Singh
dc.contributor.authorLevy, Gahl
dc.contributor.authorBehrends, Christian
dc.contributor.authorTooze, Sharon A
dc.contributor.authorMouilleron, Stephane
dc.contributor.authorLamark, Trond
dc.contributor.authorJohansen, Terje
dc.date.accessioned2022-02-24T14:07:08Z
dc.date.available2022-02-24T14:07:08Z
dc.date.issued2021-05-26
dc.description.abstractMitophagy is the degradation of surplus or damaged mitochondria by autophagy. In addition to programmed and stress-induced mitophagy, basal mitophagy processes exert organelle quality control. Here, we show that the sorting and assembly machinery (SAM) complex protein SAMM50 interacts directly with ATG8 family proteins and p62/SQSTM1 to act as a receptor for a basal mitophagy of components of the SAM and mitochondrial contact site and cristae organizing system (MICOS) complexes. SAMM50 regulates mitochondrial architecture by controlling formation and assembly of the MICOS complex decisive for normal cristae morphology and exerts quality control of MICOS components. To this end, SAMM50 recruits ATG8 family proteins through a canonical LIR motif and interacts with p62/SQSTM1 to mediate basal mitophagy of SAM and MICOS components. Upon metabolic switch to oxidative phosphorylation, SAMM50 and p62 cooperate to mediate efficient mitophagy.en_US
dc.identifier.citationAbudu YP, Shrestha BK, Zhang W, Palara A, Brenne HB, Larsen KBL, Wolfson DL, Dumitriu GA, Øie CI, Ahluwalia BS, Levy G, Behrends C, Tooze SA, Mouilleron S, Lamark T, Johansen T. SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components. Journal of Cell Biology. 2021;220(8)en_US
dc.identifier.cristinIDFRIDAID 1912433
dc.identifier.doi10.1083/jcb.202009092
dc.identifier.issn0021-9525
dc.identifier.issn1540-8140
dc.identifier.urihttps://hdl.handle.net/10037/24143
dc.language.isoengen_US
dc.publisherRockefeller University Pressen_US
dc.relation.journalJournal of Cell Biology
dc.relation.projectIDKreftforeningen: 190214en_US
dc.relation.projectIDNorges forskningsråd: 249884en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleSAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS componentsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel