Autophagy in major human diseases
dc.contributor.author | Klionsky, Daniel J. | |
dc.contributor.author | Petroni, Giulia | |
dc.contributor.author | Amaravadi, Ravi K | |
dc.contributor.author | Baehrecke, Eric H | |
dc.contributor.author | Ballabio, Andrea | |
dc.contributor.author | Boya, Patricia | |
dc.contributor.author | Bravo-San Pedro, José Manuel | |
dc.contributor.author | Cadwell, Ken | |
dc.contributor.author | Cecconi, Francesco | |
dc.contributor.author | Choi, Augustine M K | |
dc.contributor.author | Choi, Mary E | |
dc.contributor.author | Chu, Charleen T. | |
dc.contributor.author | Codogno, Patrice | |
dc.contributor.author | Colombo, Maria Isabel | |
dc.contributor.author | Cuervo, Ana Maria | |
dc.contributor.author | Deretic, Vojo | |
dc.contributor.author | Dikic, Ivan | |
dc.contributor.author | Elazar, Zvulun | |
dc.contributor.author | Eskelinen, Eeva-Liisa | |
dc.contributor.author | Fimia, Gian Maria | |
dc.contributor.author | Gewirtz, David A. | |
dc.contributor.author | Green, Douglas R. | |
dc.contributor.author | Hansen, Malene | |
dc.contributor.author | Jäättelä, Marja | |
dc.contributor.author | Johansen, Terje | |
dc.contributor.author | Juhász, Gábor | |
dc.contributor.author | Karantza, Vassiliki | |
dc.contributor.author | Kraft, Claudine | |
dc.contributor.author | Kroemer, Guido | |
dc.contributor.author | Ktistakis, Nicholas T | |
dc.contributor.author | Kumar, Sharad | |
dc.contributor.author | López-Ótin, Carlos | |
dc.contributor.author | Macleod, Kay F | |
dc.contributor.author | Madeo, Frank | |
dc.contributor.author | Martinez, Jennifer | |
dc.contributor.author | Melendez, Alicia | |
dc.contributor.author | Mizushima, Noboru | |
dc.contributor.author | Münz, Christian | |
dc.contributor.author | Penninger, Josef M. | |
dc.contributor.author | Perera, Rushika M. | |
dc.contributor.author | Piacentini, Mauro | |
dc.contributor.author | Reggiori, Fulvio | |
dc.contributor.author | Rubinsztein, David C. | |
dc.contributor.author | Ryan, Kevin M. | |
dc.contributor.author | Sadoshima, Junichi | |
dc.contributor.author | Santambrogio, Laura | |
dc.contributor.author | Scorrano, Luca | |
dc.contributor.author | Simon, Hans-Uwe | |
dc.contributor.author | Simon, Anna Katharina | |
dc.contributor.author | Simonsen, Anne | |
dc.contributor.author | Stolz, Alexandra | |
dc.contributor.author | Tavernarakis, Nektarios | |
dc.contributor.author | Tooze, Sharon A. | |
dc.contributor.author | Yoshimori, Tamotsu | |
dc.contributor.author | Yuan, Junying | |
dc.contributor.author | Yue, Zhenyu | |
dc.contributor.author | Zhong, Qing | |
dc.contributor.author | Galluzzi, Lorenzo | |
dc.contributor.author | Pietrocola, Federico | |
dc.date.accessioned | 2022-02-26T13:09:28Z | |
dc.date.available | 2022-02-26T13:09:28Z | |
dc.date.issued | 2021-08-30 | |
dc.description.abstract | Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders. | en_US |
dc.identifier.citation | Klionsky DJ, Petroni, Amaravadi, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen E, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, Juhász G, Karantza V, Kraft C, Kroemer G, Ktistakis NT, Kumar S, López-Ótin C, Macleod KF, Madeo F, Martinez J, Melendez A, Mizushima N, Münz C, Penninger JM, Perera, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Santambrogio L, Scorrano L, Simon H, Simon AK, Simonsen A, Stolz, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Galluzzi L, Pietrocola F. Autophagy in major human diseases. EMBO Journal. 2021;40:e108863 | en_US |
dc.identifier.cristinID | FRIDAID 1983469 | |
dc.identifier.doi | 10.15252/embj.2021108863 | |
dc.identifier.issn | 0261-4189 | |
dc.identifier.issn | 1460-2075 | |
dc.identifier.uri | https://hdl.handle.net/10037/24162 | |
dc.language.iso | eng | en_US |
dc.publisher | EMBO Press | en_US |
dc.relation.journal | EMBO Journal | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2021 The Author(s) | en_US |
dc.title | Autophagy in major human diseases | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |