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dc.contributor.authorHarmand, Thibault
dc.contributor.authorIslam, Md Ashraful
dc.contributor.authorPishesha, Novalia
dc.contributor.authorPloegh, Hidde L.
dc.date.accessioned2022-03-07T08:21:00Z
dc.date.available2022-03-07T08:21:00Z
dc.date.issued2021-03-08
dc.description.abstractIn vivo imaging has become in recent years an incredible tool to study biological events and has found critical applications in diagnostic medicine. Although a lot of efforts and applications have been achieved using monoclonal antibodies, other types of delivery agents are being developed. Among them, VHHs, antigen binding fragments derived from camelid heavy chain–only antibodies, also known as nanobodies, have particularly attracted attention. Indeed, their stability, fast clearance, good tissue penetration, high solubility, simple cloning and recombinant production make them attractive targeting agents for imaging modalities such as PET, SPECT or Infra-Red. In this review, we discuss the pioneering work that has been carried out using VHHs and summarize the recent developments that have been made using nanobodies for in vivo, non-invasive, imaging.en_US
dc.identifier.citationHarmand, Islam A, Pishesha, Ploegh HL. Nanobodies as in vivo, non-invasive, imaging agents RSC Chemical Biology. 2021, 2, 685en_US
dc.identifier.cristinIDFRIDAID 1897478
dc.identifier.doi10.1039/D1CB00023C
dc.identifier.issn2633-0679
dc.identifier.urihttps://hdl.handle.net/10037/24280
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.journalRSC Chemical Biology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleNanobodies as in vivo, non-invasive, imaging agentsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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