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dc.contributor.authorAglago, Elom K.
dc.contributor.authorMayén, Ana-Lucia
dc.contributor.authorKnaze, Viktoria
dc.contributor.authorFreisling, Heinz
dc.contributor.authorFedirko, Veronika
dc.contributor.authorHughes, David J.
dc.contributor.authorJiao, Li
dc.contributor.authorEriksen, Anne Kirstine
dc.contributor.authorTjønneland, Anne
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorRothwell, Joseph A.
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKatzke, Verena
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorBirukov, Anna
dc.contributor.authorPalli, Domenico
dc.contributor.authorSieri, Sabina
dc.contributor.authorde Magistris, Maria Santucci
dc.contributor.authorTumino, Rosario
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorBueno-De-Mesquita, Bas
dc.contributor.authorDerksen, Jeroen W.G.
dc.contributor.authorSkeie, Guri
dc.contributor.authorGram, Inger Torhild
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorQuirós, J. Ramón
dc.contributor.authorLujan-Barroso, Leila
dc.contributor.authorSánchez, Maria-Jose
dc.contributor.authorAmiano, Pilar
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorManjer, Jonas
dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorGunter, Marc
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorSchalkwijk, Casper G.
dc.contributor.authorJenab, Mazda
dc.date.accessioned2022-03-08T10:11:11Z
dc.date.available2022-03-08T10:11:11Z
dc.date.issued2021-09-08
dc.description.abstractDietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: Nε -carboxy-methyllysine (CML), Nε -carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HR<sub>Q5vs.Q1</sub> = 0.92, 95% CI = 0.85–1.00) and MG-H1 (HR<sub>Q5vs.Q1</sub> = 0.92, 95% CI = 0.85–1.00), but not for CEL (HR<sub>Q5vs.Q1</sub> = 0.97, 95% CI = 0.89–1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.en_US
dc.identifier.citationAglago, Mayén, Knaze, Freisling, Fedirko, Hughes, Jiao, Eriksen, Tjønneland, Boutron-Ruault, Rothwell, Severi, Kaaks, Katzke, Schulze, Birukov, Palli, Sieri, de Magistris, Tumino, Ricceri, Bueno-De-Mesquita, Derksen, Skeie, Gram, Sandanger, Quirós, Lujan-Barroso, Sánchez, Amiano, Chirlaque, Barricarte, Johansson, Manjer, Perez-Cornago, Weiderpass, Gunter, Heath, Schalkwijk, Jenab. Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study. Nutrients. 2021;13(9)en_US
dc.identifier.cristinIDFRIDAID 2007412
dc.identifier.doi10.3390/nu13093132
dc.identifier.issn2072-6643
dc.identifier.urihttps://hdl.handle.net/10037/24322
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalNutrients
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleDietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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