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dc.contributor.authorHansen, Ellen-Sofie
dc.contributor.authorRinde, Fridtjof Balteskard
dc.contributor.authorEdvardsen, Magnus
dc.contributor.authorHindberg, Kristian
dc.contributor.authorLatysheva, Nadezhda
dc.contributor.authorAukrust, Pål
dc.contributor.authorUeland, Thor
dc.contributor.authorMichelsen, Annika Elisabet
dc.contributor.authorHansen, John Bjarne
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorMorelli, Vania Maris
dc.date.accessioned2022-03-11T10:36:01Z
dc.date.available2022-03-11T10:36:01Z
dc.date.issued2021-10-25
dc.description.abstract<p><i>Background</i> D-dimer, a global biomarker for activation of the coagulation and fibrinolysis systems, is useful in assessing individual risk of venous thromboembolism (VTE) recurrence. However, there is limited information on the association between D-dimer and risk of a first lifetime VTE event. <p><i>Objectives</i> To investigate the association between plasma D-dimer levels and risk of future incident VTE. <p><i>Methods</i> A population-based nested case-control study, comprising 414 VTE patients and 843 randomly selected age- and sex-matched controls, was derived from the Tromsø Study (1994–2007). D-dimer was measured in plasma samples collected at cohort baseline (1994–95). Odds ratios (ORs) for VTE with 95% confidence intervals (CIs) were estimated according to quartile cut-offs of D-dimer levels determined in controls. <p><i>Results</i> The risk of VTE increased across quartiles of D-dimer levels (P<sub>trend</sub> = 0.014) in the age- and sex-adjusted model. Participants with plasma D-dimer levels in the highest quartile (≥152 ng/mL) had an OR for VTE of 1.65 (95% CI 1.14–2.40) compared with those in the lowest quartile (<94 ng/mL). The ORs were marginally attenuated after additional adjustment for body mass index (BMI) (OR 1.51, 95% CI 1.04–2.20) and C-reactive protein (CRP) (OR 1.34, 95% CI 0.90–1.98). Similar results were obtained for VTE subgroups, i.e. deep vein thrombosis, pulmonary embolism, and provoked/unprovoked events. <p><i>Conclusion</i> Our results indicate that elevated plasma D-dimer levels are associated with increased risk of incident VTE. However, the attenuation of risk estimates upon additional adjustment for BMI and CRP suggests that D-dimer partly reflects underlying conditions associated with obesity and an inflammatory state.en_US
dc.identifier.citationHansen E, Rinde FB, Edvardsen M, Hindberg K, Latysheva N, Aukrust P, Ueland T, Michelsen A, Hansen JB, Brækkan SK, Morelli VM. Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism. Thrombosis Research. 2021;208:121-126en_US
dc.identifier.cristinIDFRIDAID 1966977
dc.identifier.doi10.1016/j.thromres.2021.10.020
dc.identifier.issn0049-3848
dc.identifier.issn1879-2472
dc.identifier.urihttps://hdl.handle.net/10037/24386
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofRinde, F.B. (2023). D-dimer for diagnosis and risk assessment of first and recurrent venous thromboembolism. (Doctoral thesis). <a href=https://hdl.handle.net/10037/29270>https://hdl.handle.net/10037/29270</a>.
dc.relation.journalThrombosis Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleElevated plasma D-dimer levels are associated with risk of future incident venous thromboembolismen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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