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dc.contributor.authorSkille, Hanne
dc.contributor.authorPaulsen, Benedikte
dc.contributor.authorHveem, Kristian
dc.contributor.authorSeverinsen, Marianne T.
dc.contributor.authorGabrielsen, Maiken Elvestad
dc.contributor.authorKristensen, Søren R.
dc.contributor.authorNæss, Inger Anne
dc.contributor.authorHindberg, Kristian
dc.contributor.authorTjønneland, Anne
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2022-03-29T12:13:18Z
dc.date.available2022-03-29T12:13:18Z
dc.date.issued2021-07-01
dc.description.abstractBackground - Studies have reported that the combination of some prothrombotic genotypes and overt cancer yields a synergistic effect on VTE risk. Whether individual prothrombotic genotypes or number of risk alleles in a genetic risk score (GRS) affect VTE risk in occult cancer have not been addressed. The aim of this study was to investigate the joint effect of five prothrombotic genotypes and occult cancer on VTE risk.<p> <p>Methods - Cases with incident VTE (n = 1566) and a subcohort (n = 14,537) were sampled from the Scandinavian Thrombosis and Cancer Cohort (1993–2012). Five single nucleotide polymorphisms previously reported in a GRS were genotyped: ABO (rs8176719), F5 (rs6025), F2 (rs1799963), FGG (rs2066865) and F11 (rs2036914). Hazard ratios (HRs) for VTE by individual SNPs and GRS were estimated according to non-cancer and occult cancer (one year preceding a cancer diagnosis) exposure.<p> <p>Results - Occult cancer occurred in 1817 subjects, and of these, 93 experienced a VTE. The VTE risk was 4-fold higher (HR 4.05, 95% CI 3.28–5.00) in subjects with occult cancer compared with those without cancer. Among subjects with occult cancer, those with VTE had a higher proportion of prothrombotic and advanced cancers than those without VTE. The VTE risk increased according to individual prothrombotic genotypes and GRS in cancer-free subjects, while no such effect was observed in subjects with occult cancer (HR for ≥4 versus ≤1 risk alleles in GRS: 1.14, 95% CI 0.61–2.11).<p> <p>Conclusions - Five well-established prothrombotic genotypes, individually or combined, were not associated with increased risk of VTE in individuals with occult cancer.en_US
dc.identifier.citationSkille, Paulsen, Hveem, Severinsen, Gabrielsen, Kristensen, Næss, Hindberg, Tjønneland, Brækkan, Hansen. Prothrombotic genotypes and risk of venous thromboembolism in occult cancer. Thrombosis Research. 2021;205:17-23en_US
dc.identifier.cristinIDFRIDAID 1924444
dc.identifier.doi10.1016/j.thromres.2021.06.019
dc.identifier.issn0049-3848
dc.identifier.issn1879-2472
dc.identifier.urihttps://hdl.handle.net/10037/24630
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalThrombosis Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleProthrombotic genotypes and risk of venous thromboembolism in occult canceren_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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