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dc.contributor.authorMons, Ute
dc.contributor.authorMuezzinler, Aysel
dc.contributor.authorGellert, Carolin
dc.contributor.authorSchöttker, Ben
dc.contributor.authorAbnet, Christian C.
dc.contributor.authorBobak, Martin
dc.contributor.authorde Groot, Lisette
dc.contributor.authorFreedman, Neal D.
dc.contributor.authorJansen, Eugène
dc.contributor.authorKee, Frank
dc.contributor.authorKromhout, Daan
dc.contributor.authorKuulasmaa, Kari
dc.contributor.authorLaatikainen, Tiina
dc.contributor.authorO’Doherty, Mark G.
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.contributor.authorOrfanos, Philippos
dc.contributor.authorPeters, Annette
dc.contributor.authorvan der Schouw, Yvonne T.
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorWolk, Alicja
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorBoffetta, Paolo
dc.contributor.authorBrenner, Hermann
dc.date.accessioned2022-04-19T10:35:50Z
dc.date.available2022-04-19T10:35:50Z
dc.date.issued2015-04-20
dc.description.abstractObjective To investigate the impact of smoking and smoking cessation on cardiovascular mortality, acute coronary events, and stroke events in people aged 60 and older, and to calculate and report risk advancement periods for cardiovascular mortality in addition to traditional epidemiological relative risk measures.<p> <p>Design Individual participant meta-analysis using data from 25 cohorts participating in the CHANCES consortium. Data were harmonised, analysed separately employing Cox proportional hazard regression models, and combined by meta-analysis.<p> <p>Results Overall, 503?905 participants aged 60 and older were included in this study, of whom 37?952 died from cardiovascular disease. Random effects meta-analysis of the association of smoking status with cardiovascular mortality yielded a summary hazard ratio of 2.07 (95% CI 1.82 to 2.36) for current smokers and 1.37 (1.25 to 1.49) for former smokers compared with never smokers. Corresponding summary estimates for risk advancement periods were 5.50 years (4.25 to 6.75) for current smokers and 2.16 years (1.38 to 2.39) for former smokers. The excess risk in smokers increased with cigarette consumption in a dose-response manner, and decreased continuously with time since smoking cessation in former smokers. Relative risk estimates for acute coronary events and for stroke events were somewhat lower than for cardiovascular mortality, but patterns were similar.<p> <p>Conclusions Our study corroborates and expands evidence from previous studies in showing that smoking is a strong independent risk factor of cardiovascular events and mortality even at older age, advancing cardiovascular mortality by more than five years, and demonstrating that smoking cessation in these age groups is still beneficial in reducing the excess risk.en_US
dc.identifier.citationMons, Muezzinler A, Gellert C, Schöttker B, Abnet, Bobak M, de Groot L, Freedman, Jansen E, Kee F, Kromhout D, Kuulasmaa K, Laatikainen T, O’Doherty, Bueno-de-Mesquita HB, Orfanos P, Peters A, van der Schouw YT, Wilsgaard T, Wolk A, Trichopoulou A, Boffetta P, Brenner H. Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: Meta-analysis of Individual participant data from prospective cohort studies of the CHANCES consortium. BMJ. British Medical Journal. 2015;350:h1551en_US
dc.identifier.cristinIDFRIDAID 1313855
dc.identifier.doi10.1136/bmj.h1551
dc.identifier.issn1756-1833
dc.identifier.urihttps://hdl.handle.net/10037/24801
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.journalBMJ. British Medical Journal
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-HEALTH/201413/EU/European Network for Genetic and Genomic Epidemiology/ENGAGE/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-HEALTH/278913/EU/Biomarker for Cardiovascular Risk Assessment in Europe/BIOMARCARE/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-INFRASTRUCTURES/261982/EU/Multinational Advancement of Research Infrastructures on Ageing/SHARE_M4/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP5-LIFE QUALITY/QLK6-CT-2001-00360 /EU/Survey on health, ageing and retirement in europe/SHARE/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-INFRASTRUCTURES/227822/EU/Longitudinal Enhancement and Access imProvement of the SHARE infrastructure/SHARE_LEAP/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-INFRASTRUCTURES/211909/EU/ Upgrading the Survey of Health, Ageing and Retirement in Europe – preparatory phase/SHARE-PREP/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2015 BMJ Publishing Group Ltden_US
dc.titleImpact of smoking and smoking cessation on cardiovascular events and mortality among older adults: Meta-analysis of Individual participant data from prospective cohort studies of the CHANCES consortiumen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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