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dc.contributor.authorTofigh, Ali
dc.contributor.authorSuderman, Matthew
dc.contributor.authorPaquet, Eric R.
dc.contributor.authorLivingstone, Julie
dc.contributor.authorBertos, Nicholas
dc.contributor.authorSaleh, Sadiq M.
dc.contributor.authorZhao, Hong
dc.contributor.authorSouleimanova, Margarita
dc.contributor.authorCory, Sean
dc.contributor.authorLesurf, Robert
dc.contributor.authorShahalizadeh, Solmaz
dc.contributor.authorGarcia Lopez, Norberto
dc.contributor.authorRiazalhosseini, Yasser
dc.contributor.authorOmeroglu, Atilla
dc.contributor.authorUrsini-Siegel, Josie
dc.contributor.authorPark, Morag
dc.contributor.authorDumeaux, Vanessa
dc.contributor.authorHallett, Michael
dc.date.accessioned2022-05-05T07:44:43Z
dc.date.available2022-05-05T07:44:43Z
dc.date.issued2014-10-02
dc.description.abstractBreast carcinoma (BC) has been extensively profiled by high-throughput technologies for over a decade, and broadly speaking, these studies can be grouped into those that seek to identify patient subtypes (studies of heterogeneity) or those that seek to identify gene signatures with prognostic or predictive capacity. The sheer number of reported signatures has led to speculation that everything is prognostic in BC. Here, we show that this ubiquity is an apparition caused by a poor understanding of the interrelatedness between subtype and the molecular determinants of prognosis. Our approach constructively shows how to avoid confounding due to a patient’s subtype, clinicopathological profile, or treatment profile. The approach identifies patients who are predicted to have good outcome at time of diagnosis by all available clinical and molecular markers but who experience a distant metastasis within 5 years. These inherently difficult patients ( 7% of BC) are prioritized for investigations of intratumoral heterogeneity.en_US
dc.identifier.citationTofigh, Suderman, Paquet, Livingstone, Bertos, Saleh, Zhao H, Souleimanova, Cory, Lesurf, Shahalizadeh, Garcia Lopez, Riazalhosseini, Omeroglu, Ursini-Siegel J, Park M, Dumeaux V, Hallett M. The prognostic ease and difficulty of invasive breast carcinoma. Cell reports. 2014;9(1):129-142en_US
dc.identifier.cristinIDFRIDAID 1226598
dc.identifier.doi10.1016/j.celrep.2014.08.073
dc.identifier.issn2211-1247
dc.identifier.urihttps://hdl.handle.net/10037/25015
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalCell reports
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/232997/EU/TRANSCRIPTOMICS IN CANCER EPIDEMIOLOGY/TICE/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2014 The Author(s)en_US
dc.titleThe prognostic ease and difficulty of invasive breast carcinomaen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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