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dc.contributor.authorLawrance, Ian
dc.contributor.authorRogler, Gerhard
dc.contributor.authorBamias, Giorgos
dc.contributor.authorBreynaert, Chrstine
dc.contributor.authorFlorholmen, Jon
dc.contributor.authorPellino, Gianluca
dc.contributor.authorReif, Shimon
dc.contributor.authorSpeca, Silvia
dc.contributor.authorLatella, Giovanni
dc.date.accessioned2022-06-02T09:14:32Z
dc.date.available2022-06-02T09:14:32Z
dc.date.issued2015-11-02
dc.description.abstractIntestinal fibrosis is a major complication of the inflammatory bowel diseases (IBD) and although inflammation is necessary for its development, it would appear that it plays a minor role in its progression as anti-inflammatory treatments in IBD do not prevent fibrosis once it has started. The processes that regulate fibrosis would thus appear to be distinct from those regulating inflammation and, therefore, a detailed understanding of these pathways is vital to the development of antifibrogenic strategies. There have been several recent reviews exploring what is known, and what remains unknown, about the development of intestinal fibrosis. This review is designed to add to this literature but with a focus on the cellular components that are involved in the development of fibrogenesis and the major molecular mediators that impact on these cells. The aim is to heighten the understanding of the factors involved in intestinal fibrogenesis so that detailed research can be encouraged in order to advance the processes that could lead to effective treatments.en_US
dc.identifier.citationIan C Lawrance, Gerhard Rogler, Giorgos Bamias, Christine Breynaert, Jon Florholmen, Gianluca Pellino, Shimon Reif, Silvia Speca, Giovanni Latella, Cellular and Molecular Mediators of Intestinal Fibrosis, Journal of Crohn's and Colitis, Volume 11, Issue 12, December 2017, Pages 1491–1503en_US
dc.identifier.cristinIDFRIDAID 1199485
dc.identifier.doi10.1016/j.crohns.2014.09.008
dc.identifier.issn1873-9946
dc.identifier.issn1876-4479
dc.identifier.urihttps://hdl.handle.net/10037/25352
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalJournal of Crohn's and Colitis
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2015 Oxford University Pressen_US
dc.titleCellular and molecular mediators of intestinal fibrosisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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