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dc.contributor.authorDardente, Hugues
dc.contributor.authorHazlerigg, David
dc.contributor.authorEbling, Francis J.P.
dc.date.accessioned2022-06-03T10:51:01Z
dc.date.available2022-06-03T10:51:01Z
dc.date.issued2014-02-26
dc.description.abstractLiving organisms show seasonality in a wide array of functions such as reproduction, fattening, hibernation, and migration. At temperate latitudes, changes in photoperiod maintain the alignment of annual rhythms with predictable changes in the environment.The appropriate physiological response to changing photoperiod in mammals requires retinal detection of light and pineal secretion of melatonin, but extraretinal detection of light occurs in birds. A common mechanism across all vertebrates is that these photoperiod-regulated systems alter hypothalamic thyroid hormone (TH) conversion. Here, we review the evidence that a circadian clock within the pars tuberalis of the adenohypophysis links photoperiod decoding to local changes of TH signaling within the medio-basal hypothalamus (MBH) through a conserved thyrotropin/deiodinase axis. We also focus on recent findings which indicate that, beyond the photoperiodic control of its conversion,TH might also be involved in longerterm timing processes of seasonal programs. Finally, we examine the potential implication of kisspeptin and RFRP3, two RF-amide peptides expressed within the MBH, in seasonal rhythmicity.en_US
dc.identifier.citationDardente, Hazlerigg D, Ebling FJ. Thyroid hormone and seasonal rhythmicity. Frontiers in Endocrinology. 2014;5:19en_US
dc.identifier.cristinIDFRIDAID 1224527
dc.identifier.doi10.3389/fendo.2014.00019
dc.identifier.issn1664-2392
dc.identifier.urihttps://hdl.handle.net/10037/25370
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Endocrinology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2014 The Author(s)en_US
dc.titleThyroid hormone and seasonal rhythmicityen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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