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dc.contributor.authorVimaleswaran, Kerani S.
dc.contributor.authorCavadino, Alana
dc.contributor.authorBerry, Diane J.
dc.contributor.authorJorde, Rolf
dc.contributor.authorGrimnes, Guri
dc.contributor.authorDieffenbach, Aida Karina
dc.contributor.authorLu, Chen
dc.contributor.authorAlves, Alexessander Couto
dc.contributor.authorHeerspink, Hiddo J. Lambers
dc.contributor.authorTikkanen, Emmi
dc.contributor.authorEriksson, Joel
dc.contributor.authorWong, Andrew
dc.contributor.authorMangino, Massimo
dc.contributor.authorJablonski, Kathleen A.
dc.contributor.authorNolte, Ilja M.
dc.contributor.authorHouston, Denise K.
dc.contributor.authorAhluwalia, Tarunveer Singh
dc.contributor.authorvan der Most, Peter J.
dc.contributor.authorPasko, Dorota
dc.contributor.authorZgaga, Lina
dc.contributor.authorThiering, Elisabeth
dc.contributor.authorSchöttker, B
dc.contributor.authorSaum, KU
dc.contributor.authorBrenner, H
dc.contributor.authorJärvelin, MR
dc.contributor.authorTzoulaki, I
dc.contributor.authorSnieder, H
dc.contributor.authorStolk, RP
dc.contributor.authorHartman, CA
dc.contributor.authorde Boer, RA
dc.contributor.authorvan der Harst, P
dc.contributor.authorNavis, G
dc.contributor.authorde Borst, MH
dc.contributor.authorLorentzon, M
dc.contributor.authorMellström, D
dc.contributor.authorOhlsson, C
dc.contributor.authorHardy, R
dc.contributor.authorKuh, D
dc.contributor.authorCooper, JA
dc.contributor.authorAcharya, J
dc.contributor.authorHumphries, SE
dc.contributor.authorHingorani, AD
dc.contributor.authorKumari, M
dc.contributor.authorKivimaki, M
dc.contributor.authorSpector, TD
dc.contributor.authorKritchevsky, SB
dc.contributor.authorLohman, KK
dc.contributor.authorSørensen, TIA
dc.contributor.authorFrayling, TM
dc.contributor.authorCampbell, H
dc.contributor.authorTheodoratou, E
dc.contributor.authorFraser, RM
dc.contributor.authorWilson, JF
dc.contributor.authorRudan, I
dc.contributor.authorPrice, JF
dc.contributor.authorMcLachlan, S
dc.contributor.authorVitart, V
dc.contributor.authorNavarro, P
dc.contributor.authorHuffman, JE
dc.contributor.authorHayward, C
dc.contributor.authorWright, AF
dc.contributor.authorTiesler, CMT
dc.contributor.authorHeinrich, J
dc.contributor.authorMcCarthy, MI
dc.contributor.authorIngelsson, E
dc.contributor.authorArden, N
dc.contributor.authorCooper, C
dc.contributor.authorDupuis, J
dc.contributor.authorHerzig, KH
dc.contributor.authorSebert, S
dc.contributor.authorPouta, A
dc.contributor.authorLaitinen, J
dc.contributor.authorKleber, ME
dc.contributor.authorMärz, W
dc.contributor.authorJameson, K
dc.contributor.authorOsmond, C
dc.contributor.authorRaitakari, O
dc.contributor.authorRipatti, S
dc.contributor.authorLahti, J
dc.contributor.authorEriksson, JG
dc.contributor.authorPenninx, BW
dc.contributor.authorBillings, LK
dc.contributor.authorFlorez, JC
dc.contributor.authorRejnmark, L
dc.contributor.authorLangdahl, BL
dc.contributor.authorPaternoster, L
dc.contributor.authorHernandez, DG
dc.contributor.authorByberg, L
dc.contributor.authorMichaelsson, K
dc.contributor.authorHagström, E
dc.contributor.authorMelhus, H
dc.contributor.authorLjunggren, O
dc.contributor.authorLind, L
dc.contributor.authorJula, A
dc.contributor.authorPolasek, O
dc.contributor.authorSalomaa, V
dc.contributor.authorKarlsson, M
dc.contributor.authorBandinelli, S
dc.contributor.authorLehtimäki, T
dc.contributor.authorWang, TJ
dc.contributor.authorPilz, S
dc.contributor.authorWhittaker, JC
dc.date.accessioned2022-06-08T10:54:55Z
dc.date.available2022-06-08T10:54:55Z
dc.date.issued2014-06-25
dc.description.abstractBackground Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk.<p> <p>Methods In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that aff ect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108 173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We complemented these analyses with previously published summary statistics from the International Consortium on Blood Pressure (ICBP), the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and the Global Blood Pressure Genetics (Global BPGen) consortium. <p>Findings In phenotypic analyses (up to n=49 363), increased 25(OH)D concentration was associated with decreased systolic blood pressure (β per 10% increase, –0·12 mm Hg, 95% CI –0·20 to –0·04; p=0·003) and reduced odds of hypertension (odds ratio [OR] 0·98, 95% CI 0·97–0·99; p=0·0003), but not with decreased diastolic blood pressure (β per 10% increase, –0·02 mm Hg, –0·08 to 0·03; p=0·37). In meta-analyses in which we combined data from D-CarDia and the ICBP (n=146 581, after exclusion of overlapping studies), each 25(OH)D-increasing allele of the synthesis score was associated with a change of –0·10 mm Hg in systolic blood pressure (–0·21 to –0·0001; p=0·0498) and a change of –0·08 mm Hg in diastolic blood pressure (–0·15 to –0·02; p=0·01). When D-CarDia and consortia data for hypertension were meta-analysed together (n=142 255), the synthesis score was associated with a reduced odds of hypertension (OR per allele, 0·98, 0·96–0·99; p=0·001). In instrumental variable analysis, each 10% increase in genetically instrumented 25(OH)D concentration was associated with a change of –0·29 mm Hg in diastolic blood pressure (–0·52 to –0·07; p=0·01), a change of –0·37 mm Hg in systolic blood pressure (–0·73 to 0·003; p=0·052), and an 8·1% decreased odds of hypertension (OR 0·92, 0·87–0·97; p=0·002). <p>Interpretation Increased plasma concentrations of 25(OH)D might reduce the risk of hypertension. This fi nding warrants further investigation in an independent, similarly powered study.en_US
dc.identifier.citationVimaleswaran, Cavadino A, Berry, Jorde r, Grimnes G, Dieffenbach AK, Lu, Alves AC, Heerspink, Tikkanen E, Eriksson J, Wong A, Mangino M, Jablonski, Nolte, Houston, Ahluwalia TS, van der Most, Pasko D, Zgaga L, Thiering, Schöttker B, Saum, Brenner H, Järvelin, Tzoulaki I, Snieder H, Stolk R, Hartman, de Boer R, van der Harst P, Navis G, de Borst, Lorentzon M, Mellström, Ohlsson C, Hardy R, Kuh D, Cooper J, Acharya, Humphries S, Hingorani A, Kumari M, Kivimaki M, Spector T, Kritchevsky S, Lohman K, Sørensen, Frayling T, Campbell H, Theodoratou, Fraser R, Wilson J, Rudan I, Price J, McLachlan S, Vitart V, Navarro P, Huffman J, Hayward C, Wright A, Tiesler C, Heinrich J, McCarthy M, Ingelsson E, Arden, Cooper C, Dupuis J, Herzig K, Sebert, Pouta A, Laitinen J, Kleber M, März, Jameson K, Osmond, Raitakari O, Ripatti S, Lahti J, Eriksson J, Penninx B, Billings, Florez J, Rejnmark L, Langdahl B, Paternoster L, Hernandez D, Byberg L, Michaelsson K, Hagström, Melhus H, Ljunggren O, Lind L, Jula A, Polasek O, Salomaa V, Karlsson M, Bandinelli S, Lehtimäki, Wang T, Pilz, Whittaker. Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study. The Lancet Diabetes and Endocrinology. 2014;2(9):719-729en_US
dc.identifier.cristinIDFRIDAID 1217735
dc.identifier.doi10.1016/S2213-8587(14)70113-5
dc.identifier.issn2213-8587
dc.identifier.issn2213-8595
dc.identifier.urihttps://hdl.handle.net/10037/25398
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalThe Lancet Diabetes and Endocrinology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2014 The Author(s)en_US
dc.titleAssociation of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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