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dc.contributor.authorArild, Anette
dc.contributor.authorVangberg, Torgil Riise
dc.contributor.authorNikkels, Hanne
dc.contributor.authorLydersen, Stian
dc.contributor.authorWisløff, Ulrik
dc.contributor.authorStensvold, Dorthe
dc.contributor.authorHåberg, Asta
dc.date.accessioned2022-08-04T09:25:45Z
dc.date.available2022-08-04T09:25:45Z
dc.date.issued2022-01-18
dc.description.abstractWe investigated if a five-year supervised exercise intervention with moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT) versus control; physical activity according to national guidelines, attenuated the growth of white matter hyperintensities (WMH). We hypothesized that supervised exercise, in particular HIIT, reduced WMH growth. Older adults from the general population participating in the RCT Generation 100 Study were scanned at 3T MRI at baseline (age 70–77), and after 1-, 3- and 5-years. At each follow-up, cardiorespiratory fitness was measured with ergospirometry, and physical activity plus clinical data collected. Manually delineated total WMH, periventricular (PWMH), deep (DWMH), and automated total white matter hypointensity volumes were obtained. No group by time interactions were present in linear mixed model analyses with the different WMH measurements as outcomes. In the combined exercise (MICT&HIIT) group, a significant group by time interaction was uncovered for PWMH volume, with a larger increase in the MICT&HIIT group. Cardiorespiratory fitness at the follow-ups or change in cardiorespiratory fitness over time were not associated with any WMH measure. Contrary to our hypothesis, taking part in MICT or HIIT over a five-year period did not attenuate WMH growth compared to being in a control group following national physical activity guidelines.en_US
dc.identifier.citationArild, Vangberg, Nikkels, Lydersen, Wisløff, Stensvold, Håberg. Five years of exercise intervention at different intensities and development of white matter hyperintensities in community dwelling older adults, a Generation 100 sub-study. Aging. 2022;14(2):596-622en_US
dc.identifier.cristinIDFRIDAID 2018967
dc.identifier.doi10.18632/aging.203843
dc.identifier.issn1945-4589
dc.identifier.urihttps://hdl.handle.net/10037/25946
dc.language.isoengen_US
dc.publisherImpact journalsen_US
dc.relation.journalAging
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleFive years of exercise intervention at different intensities and development of white matter hyperintensities in community dwelling older adults, a Generation 100 sub-studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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